Effects of Using Trichloroacetic Acid and Podophyllin on Treatment of Anogenital Warts in Sexually Transmitted Disease Clinic, Chiang Mai Province

Abstract

The treatment of anogenital warts has been generally known to be difficult, time consuming and a high rate of relapse. There are many modalities to treat anogenital warts. The Clinic for Sexually Transmitted Disease of the Office of Disease Prevention and Control region 1 (ODPC 1), Chiang Mai has been using Trichloroacetic acid and Podophyllin as two main types of topical creams to treat the disease for a long period of time. Therefore, the study conducted a descriptive method between October 2014 through September 2017 and collected retrospective data from the STD clinic. The data analytic method performed the Chi-Square and Fisher's Exact Tests. The results showed from three year period that we retrieved 118 patients who were treated with Trichloroacetic acid or with Podophyllin and  had been followed up for 6 months. Podophyllin cream was applied by 66.10% and Trichloroacetic acid cream 33.90%. The data analysis showed that Trichloroacetic acid and Podophyllin applications had significant differences in genders, sites of lesions, co-infection with other STIs, and the side effects (p<0.05). However, there was no difference in age, sexual deviance, duration of treatment, cure duration and recurrent rate. Thus, this study can be concluded that the efficacy of both regimens of therapy was not different. Treatment with trichloroacetic acid was more likely to cause side effects. If there is no contraindications, Podophyllin could be the first line of choice for treatment the disease.