Beta-catenin expression and S100-positive stromal component in basal cell adenoma: a case report and literature reviews
คำสำคัญ:
Basal cell adenoma, Beta-catenin, S100, Salivary gland neoplasmบทคัดย่อ
Objective : To present a case of basal cell adenoma (BCA) that features beta-catenin expression and S100-positive cells in the stromal component.
Method : We report a case of BCA with clinical data collected from medical records at Chaiyaphum Hospital.
Result : A 79-year-old female presented with a painless, slow-growing mass in the right parotid gland. Macroscopic examination showed a circumscribed mass, 2.7 cm in greatest dimension, in the deep lobe. Cut surfaces revealed a solid-cystic, greyish-white appearance with a rubbery consistency. Microscopic examination showed an encapsulated mass composed of basaloid and luminal cells with focal nuclear palisading at the periphery of the tumor nest. Immunohistochemical studies indicated that luminal cells were positive for EMA and CD117, while abluminal cells were positive for p63 and SMA. Beta-catenin showed nuclear localization in the peripheral cell layer and spindle stromal cells. Spindle stromal cells were diffusely positive for S100 but negative for p63, SMA, and EMA.
Conclusion : The spindle cells within the stromal component of our case showed distinct nuclear localization of beta-catenin and diffuse positivity for S100, which is rarely seen in other types of benign and malignant salivary neoplasms.
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