Prevalence of Post COVID-19 Conditions in SARS-CoV-2 Infected Patients at 3-month telephone follow-up

Authors

  • Maethawee Wangchalabovorn, MD Saraburi Hospital
  • Saran Weerametachai, MD Department of Social Medicine, Saraburi Hospital
  • Thanakamon Leesri, Ph.D. School of Community Health Nursing, Institute of Nursing, Suranaree University of Technology

Keywords:

Post-COVID, SARS-CoV-2, Long-COVID, Prevalence

Abstract

The objectives of this analytical cross-sectional study were to study the prevalence of post COVID-19 conditions in patients diagnosed with SARS-COV-2 infection and factors associated with the post COVID-19 conditions. The samples were randomly selected from 1,593 patients from Saraburi COVID-19 Healthcare Network quarantines consisted of Saraburi general hospital, a field hospital, hospitels, and home and community-based isolation (HI & CI) between July 1 and August 31, 2021. The sample were those who had at least of 3 months prior history of confirmed SARS-CoV-2 infection using proportional sampling techniques yield the sample size of 202 patients. The samples were clinically observed via tele-follow-up between November15 and December 22, 2021 using structured interviews including Fatigue Severity Scale (FFS)-Thai version (α=0.88), mMRC, and PEM screening questions (α=0.82). The estimated prevalence was calculated in weighted proportion of male and female ratio of the total infected patients.

The results showed that, among the total of 202 SARS-CoV-2 infected patients, about half were females (50.5%). The samples showed the prevalence of post-COVID conditions of 64.87 percent. The most prevalent clinical symptoms were Alopecia (32.53%), post-exertional malaise (PEM) (32.02%), Dyspnea (21.59%), Fatigue (16.46%), and Insomnia (13.77%). Being females had a significant association with Alopecia (p<0.001) and post-COVID conditions (p<0.001). Severe clinical symptoms during acute infection (p=0.004) and diabetes mellitus (p=0.012) showed significant associations with dyspnea.

Author Biographies

Maethawee Wangchalabovorn, MD, Saraburi Hospital

Medical Physician, Practitioner Level

Saran Weerametachai, MD, Department of Social Medicine, Saraburi Hospital

Medical Physician, Professional Level

Thanakamon Leesri, Ph.D., School of Community Health Nursing, Institute of Nursing, Suranaree University of Technology

Assistant Professor

References

Dong E, Du H, Gardner L. An interactive web-based dashboard to track COVID-19 in real time [Internet]. Vol. 20, The Lancet Infectious Diseases. Elsevier; 2020 [cited 2021 Oct 22]. p. 533–4. Available from: http://www.thelancet.com/article/S1473309920301201/fulltext

World Health Organization. Clinical Management of COVID-19: Living Guidance. World Heal Organ [Internet]. 2021 Oct [cited 2021 Oct 26];(January). Available from: https://www.who.int/publications/i/item/WHO-2019-nCoV-clinical-2021-2

World Health Organization. Expanding our understanding of Post COVID-19 condition [Internet]. 2021 [cited 2021 Oct 26]. Available from: https://apps.who.int/iris/handle/10665/340951

Augustin M, Schommers P, Stecher M, Dewald F, Gieselmann L, Gruell H, et al. Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study. Lancet Reg Heal - Eur [Internet]. 2021 Jul 1 [cited 2021 Oct 21];6:100122. Available from: http://www.thelancet.com/article/S2666776221000995/fulltext

Menges D, Ballouz T, Anagnostopoulos A, Aschmann HE, Domenghino A, Fehr JS, et al. Burden of post-COVID-19 syndrome and implications for healthcare service planning: A population-based cohort study. PLoS One [Internet]. 2021 Jul 1 [cited 2021 Oct 21];16(7):e0254523. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254523

Moreno-Pérez O, Merino E, Leon-Ramirez JM, Andres M, Ramos JM, Arenas-Jiménez J, et al. Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study. J Infect [Internet]. 2021 Mar 1 [cited 2021 Oct 21];82(3):378–83. Available from: http://www.journalofinfection.com/article/S0163445321000098/fulltext

Huang C, Huang L, Wang Y, Li X, Ren L, Gu X, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet [Internet]. 2021 Jan 16 [cited 2021 Oct 22];397(10270):220–32. Available from: https://pubmed.ncbi.nlm.nih.gov/33428867/

Xiong Q, Xu M, Li J, Liu Y, Zhang J, Xu Y, et al. Clinical sequelae of COVID-19 survivors in Wuhan, China: a single-centre longitudinal study. Clin Microbiol Infect [Internet]. 2021 Jan 1 [cited 2021 Dec 29];27(1):89–95. Available from: http://www.clinicalmicrobiologyandinfection.com/article/S1198743X20305759/fulltext

World Health Organization. A clinical case definition of post COVID-19 condition by a Delphi consensus, [Internet]. 2021 [cited 2021 Oct 23]. Available from: https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1

Huang L, Yao Q, Gu X, Wang Q, Ren L, Wang Y, et al. 1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study. Lancet [Internet]. 2021 Aug 28 [cited 2021 Oct 22];398(10302):747–58. Available from: https://pubmed.ncbi.nlm.nih.gov/34454673/

Liang L, Yang B, Jiang N, Fu W, He X, Zhou Y, et al. Three-month Follow-up Study of Survivors of Coronavirus Disease 2019 after Discharge. J Korean Med Sci [Internet]. 2020 Jan 1 [cited 2021 Oct 22];35(46). Available from: https://pubmed.ncbi.nlm.nih.gov/33289374/

Mughal F, Khunti K, Mallen C. The impact of COVID-19 on primary care: Insights from the Na... : Journal of Family Medicine and Primary Care [Internet]. Journal of Family Medicine and Primary Care. 2021 [cited 2021 Oct 30]. Available from: https://journals.lww.com/jfmpc/Fulltext/2021/12000/The_impact_of_COVID_19_on_primary_care__Insights.3.aspx

Pourhoseingholi MA, Vahedi M, Rahimzadeh M. Sample size calculation in medical studies. Gastroenterol Hepatol from bed to bench [Internet]. 2013;6(1):14–7. Available from: https://pubmed.ncbi.nlm.nih.gov/24834239

สวัสดี อวยพร. ปัจจัยคัดสรรที่สัมพันธ์กับความเหนื่อยล้าในผู้ป่วยโรคหลอดเลือดสมอง.[ปริญญานิพนธ์พยาบาลศาสตร์มหาบัณฑิต]. กรุงเทพฯ: จุฬาลงกรณ์มหาวิทยาลัย; 2014.

คณะทำงานพัฒนาแนวปฏิบัติการบริการสาธารณสุขโรคปอดอุดกลั้นเรื้อรัง. แนวปฏิบัติบริการสาธารณสุข โรคปอดอุดกั้นเรื้อรัง พ.ศ. 2553. สมาคมอุรเวชช์แห่งประเทศไทย;2010.

Stussman B, Williams A, Snow J, Gavin A, Scott R, Nath A, et al. Characterization of Post–exertional Malaise in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Front Neurol [Internet]. 2020 Sep 18 [cited 2021 Oct 27];11:1025. Available from: https://www.frontiersin.org/articles/10.3389/fneur.2020.01025/full

กรมสุขภาพจิต. แนวทางการดูแลเฝ้าระวังโรคซึมเศร้าระดับจังหวัด. กรมสุขภาพจิต กระทรวงสาธารณสุข [Internet]. 2014;7–8. Available from: https://www.dmh.go.th/test/download/files/2Q 9Q 8Q (1).pdf

WHO Working Group on the Clinical Characterisation and Management of COVID-19 infection. A minimal common outcome measure set for COVID-19 clinical research [Internet]. Vol. 20, The Lancet Infectious Diseases. 2020 [cited 2022 Jan 8]. p. e192–7. Available from: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30483-7/fulltext

กรมวิทยาศาสตร์การแพทย์. การเฝ้าระวังการระบาด และกลายพันธุ์โควิด-19 ในประเทศไทย 6 ส.ค.2564 [Internet]. กรุงเทพมหานคร; 2021. Available from: http://msto.dmsc.moph.go.th/login/showimgdetil.php?id=329

Hu Z, Huang X, Zhang J, Fu S, Ding D, Tao Z. Differences in Clinical Characteristics Between Delta Variant and Wild-Type SARS-CoV-2 Infected Patients. Front Med [Internet]. 2022;8. Available from: https://www.frontiersin.org/article/10.3389/fmed.2021.792135

Carruthers BM, Van de Sande MI, De Meirleir KL, Klimas NG, Broderick G, Mitchell T, et al. Myalgic encephalomyelitis: International Consensus Criteria. J Intern Med [Internet]. 2011 Oct 1 [cited 2022 Jan 15];270(4):327–38. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2796.2011.02428.x

Davis HE, Assaf GS, McCorkell L, Wei H, Low RJ, Re'em Y, et al. Characterizing Long COVID in an International Cohort: 7 Months of Symptoms and Their Impact. SSRN Electron J [Internet]. 2021 Apr 13 [cited 2021 Oct 22]; Available from: https://papers.ssrn.com/abstract=3820561

Fernández-de-las-Peñas C, Guijarro C, Torres-Macho J, Velasco-Arribas M, Plaza-Canteli S, Hernández-Barrera V, et al. Diabetes and the Risk of Long-term Post-COVID Symptoms. Diabetes [Internet]. 2021 Sep 27;70(12):2917–21. Available from: https://doi.org/10.2337/db21-0329

Verity R, Okell LC, Dorigatti I, Winskill P, Whittaker C, Imai N, et al. Estimates of the severity of coronavirus disease 2019: a model-based analysis. Lancet Infect Dis. 2020 Jun;20(6):669–77.

Centers for Disease Control and Prevention. IOM 2015 Diagnostic Criteria - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) [Internet]. Institute of Medicine. 2015 [cited 2022 Jan 5]. Available from: https://www.cdc.gov/me-cfs/healthcare-providers/diagnosis/iom-2015-diagnostic-criteria.html

Mantovani E, Mariotto S, Gabbiani D, Dorelli G, Bozzetti S, Federico A, et al. Chronic fatigue syndrome: an emerging sequela in COVID-19 survivors? J Neurovirol [Internet]. 2021/08/02. 2021 Aug;27(4):631–7. Available from: https://pubmed.ncbi.nlm.nih.gov/34341960

Kedor C, Freitag H, Meyer-Arndt L, Wittke K, Zoller T, Steinbeis F, et al. Chronic COVID-19 Syndrome and Chronic Fatigue Syndrome (ME/CFS) following the first pandemic wave in Germany – a first analysis of a prospective observational study [Internet]. medRxiv; 2021. Available from: http://europepmc.org/abstract/PPR/PPR279456

Komaroff AL, Lipkin WI. Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome. Trends Mol Med [Internet]. 2021/06/07. 2021 Sep;27(9):895–906. Available from: https://pubmed.ncbi.nlm.nih.gov/34175230

Downloads

Published

2022-03-20

How to Cite

Wangchalabovorn, M., Weerametachai, S., & Leesri, T. (2022). Prevalence of Post COVID-19 Conditions in SARS-CoV-2 Infected Patients at 3-month telephone follow-up. REGIONAL HEALTH PROMOTION CENTER 9 JOURNAL, 16(1), 265–284. retrieved from https://he02.tci-thaijo.org/index.php/RHPC9Journal/article/view/255986

Issue

Section

Research Article