Successful treatment of progressive macular hypomelanosis with narrowband UVB: A case report

Authors

  • Marinya Pongpudpunth DIVISION OF DERMATOLOGY, DEPARTMENT OF MEDICINE, FACULTY OF MEDICINE RAMATHIBODI HOSPITAL, MAHIDOL UNIVERSITY, BANGKOK, THAILAND
  • Premjit Vaiyavatjamai DIVISION OF DERMATOLOGY, DEPARTMENT OF MEDICINE, FACULTY OF MEDICINE RAMATHIBODI HOSPITAL, MAHIDOL UNIVERSITY, BANGKOK, THAILAND
  • Ploysyne Rattanakaemakorn DIVISION OF DERMATOLOGY, DEPARTMENT OF MEDICINE, FACULTY OF MEDICINE RAMATHIBODI HOSPITAL, MAHIDOL UNIVERSITY, BANGKOK, THAILAND

Keywords:

Progressive macular hypomelanosis, treatment, Narrowband ultraviolet

Abstract

Progressive macular hypomelanosis is a rare dermatosis of uncertain etiology. Propionibactrium has been postulated as the causative agent. Narrowband ultraviolet B (NB-UVB) was shown to stimulate melanogenesis accompany with antibacterial effect. It has been reported as an effective therapeutic option. Here we report a case of a 39 years old woman with hypopigmented lesions on the back over 2 months and were diagnosed as PMH. The patient was initially treated as Tinea vesicolor and topical antifungal without any improvement. Therefore, she was treateded with NB-UVB phototherapy. After complete 18 sessions, with a total cumulative dose of 20500 mj/cm2, the patient shows almost total repigmentation of the lesions.

References

Relyveld G, Menke HE, Westerhof W. Progressive macular hypomelanosis: an overview. Am J ClinDermatol 2007;8:13-9.

Kumarasinghe SP, Tan SH, Thng S, et al. Progressive macular hypomelanosis in Singapore: a clinic-pathological study. Int J Dermatol 2006;45:737-42.

Wu XG, Xu A, Zheng JH, et al. Clinical, pathologic, and ultrastructural studies of progressive macular hypomelanosis. IntJDermatol 2010;49:1127-32.

Nina BID, Buense R. Progressive macular hypomelanosis: an epidemiological study and therapeutic response to phototherapy. An Bras Dermatol 2010;85:621-4.

Motero LC, Belinchon I, Toledo F. Progressive macular hypomelanosis, excellent response with narrow-band ultraviolet B phototherapy. PhotodermatolPhotoimmunolPhotomed 2011;27:162-3.

Kwah YC, Chong WS, Theng TS, Goh BK. Treatment of progressive macular hypomelanosis with narrow-band ultraviolet B phototherapy. PhotodermatolPhotoimmunolPhotomed 2010;26;153-5.

Fluhrj W, Gloor M. The antimicrobial effect of narrow-band UVB (313 nm) and UVA1 (345-440) radiation in vitro. PhotdermatolPhotoimmunolPhotomed 1997;13;197-201

Wu CS, Yu CL, Wu CS, Lan CC, Yu HS. Narrow-band ultraviolet-B stimulates proliferation and migration of cultured melanocytes. ExpDermatol 2004;13:755-63.

Downloads

Published

2026-06-10

How to Cite

Pongpudpunth, M., Vaiyavatjamai, P., & Rattanakaemakorn, P. (2026). Successful treatment of progressive macular hypomelanosis with narrowband UVB: A case report. Thai Journal of Dermatology, 28(4), 283–286. retrieved from https://he02.tci-thaijo.org/index.php/TJD/article/view/282897