AIDS-related-Kaposi’s sarcoma: A case report
Keywords:
AIDS-related Kaposi’s sarcoma, HHV-8, CD 34Abstract
Kaposi’s sarcoma (KS), the most common neoplasm in patients with AIDS, is classified into four clinico-epidemiological types. HHV-8 infection precedes the development of all variants of KS. AIDS-related KS is one of these variants. The clinical presentations typically begin as purplish macular and papular lesions that progress to plaque-like or nodular tumors. Lesions usually occur on the head, face and upper trunk.Skin biopsy is crucial to make a correct diagnosis of KS.
We report a 30 year-old man with violaceous plaques on the face. The histology revealed numerous dilated and congested blood vessels with some slit-like vascular channels infiltrating among the collagen bundles. On the immunohistochemical examination, CD 34 staining was observed in a very large number of vessels.
References
Aboulafia DM. Regression of acquired immunodefeciency syndrome- related pulmonary kaposi sarcoma after highly active antiretroviral therapy. Mayo Clin Proc. 1998 May;73:439-43
Bourboulia D, Whitby D, Boshoff C, et al. Serologic evidence for mother-to-child transmission of Kaposi sarcoma-associated herpesvirus infection. JAMA 1998; 280: 31–32.
Plancoulaine S, Abel L, Van Beveren M, et al. Herpesvirus8 transmission from mother to child and between siblings in an endemic population. Lancet 2000; 356:1062–65.
Schwartz RA, Micali G, Nasca MR, Scuderi L. Kaposi sarcoma: a continuing conundrum. J Am AcadDerrmatol 2008;59:179-208.
Friedman- Kien AE, Laubenstein L, Marmor M, et al. Kaposi’s sarcoma and pneumocystic pneumonia among homosexual men- New York City and California. MMWR Morb Mortal Wkly Rep 1981;30:305-8.
Martin JN, Ganem DE, Osmond DH, et al. Sexual transmission and the natural history of human herpesvirus 8 infection. N Engl J Med 1998; 338: 948–54.
Hengge UR, Ruzicka T, Tyring SK, et al. Update on Kaposi’s sarcoma and other HHV8 associated diseases. Part1: epidemiology, environmental predispositions, clinical manifestations, and therapy. Lancet Infect Dis 2002;2:281-92
Sharma VS, Valji K, Bookstein JJ. Gastrointestinal hemorrhage in AIDS: arteriographic diagnosis and transcatheter treatment. Radiology 1992; 185:447-51
Lee VW, Fuller JD, O’Brien MJ, Parker DR, Cooley TP, Liebman HA. Pulmonary Kaposi sarcoma in patients with AIDS: scintigraphic diagnosis with sequential thallium and gallium scanning. Radiology 1991; 180: 409–12
Vanarthos WJ, Ganz WI, Vanarthos JC, Serafini AN, Tehranzadeh J. Diagnostic uses of nuclear medicine in AIDS. Radiographics 1992; 12: 731–49.
Ackerman AB. Subtle clues to diagnosis by conventional microscopy. The patch stage of Kaposi’s sarcoma. Am Dermatopathol 1979; 1: 165–72.
Calonje E. Vascular tumors : Tumors and tumor – like conditions of blood vessels and lymphatics. In Elder DE, editor. Lever’s Histopathology of the skin. 10th ed. Philadelphia; Wolters Kluwer, 2009.p.1007-1056.
Sturzl M, Brandstetter H, Roth WK. Kaposi’s sarcoma: a review of gene expression and ultrastructure of KS spindle cells in vivo. AIDS Res Hum Retroviruses 1992; 8: 1753–63.
Antman K, Chang Y. Kaposi’s Sarcoma. N Engl J Med 342;14:1027-1036.
Stewart S, Jablonowski H, Goebel FD, et al. Randomized comparative trial of pegylated liposomal doxorubicin versus bleomycin and vincristine in the treatment of AIDS-related Kaposiดs sarcoma. International Pegylated Liposomal Doxorubicin Study Group. JClinOncol 1998; 16: 683–91.
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เนื้อหาและข้อมูลในบทความที่ลงตีพิมพ์ในวารสารโรคผิวหนัง ถือเป็นข้อคิดเห็นและความรับผิดชอบของผู้เขียนบทความโดยตรงซึ่งกองบรรณาธิการวารสาร ไม่จำเป็นต้องเห็นด้วย หรือร่วมรับผิดชอบใดๆ
บทความ ข้อมูล เนื้อหา รูปภาพ ฯลฯ ที่ได้รับการตีพิมพ์ในวารสารโรคผิวหนัง ถือเป็นลิขสิทธิ์ของวารสารฯ หากบุคคลหรือหน่วยงานใดต้องการนำทั้งหมดหรือส่วนหนึ่งส่วนใดไปเผยแพร่ต่อหรือเพื่อกระทำการใดๆ จะต้องได้รับอนุญาตเป็นลายลักอักษรจากบรรณาธิการวารสารโรคผิวหนังก่อนเท่านั้น
