Accuracy of Fine Needle Aspiration Cytology in Diagnosis of Salivary Gland mass
Keywords:
salivary gland, fine needle aspiration cytology, accuracyAbstract
Objective: To determine the accuracy of fine needle aspiration cytology in diagnosis of salivary gland malignancy, by comparing the final pathological diagnosis with the initial FNAC result. It is helpful to diagnose and plan the management and evaluate postoperative complication in patient with salivary gland mass.
Materials and methods: Retrospective analysis of 82 patients with salivary gland mass who underwent pre-operative FNAC and surgical excision at Samutsakorn Hospital from 1 January 2010 to 30 May 2017. FNAC was correlated with histopathology. The accuracy in diagnosis of salivary gland malignancy, sensitivity, specificity, positive predictive value and negative predictive value were calculated.
Results: The overall results showed an accuracy of 95%, sensitivity of 50%, specificity of 99%, diagnostic positive predictive value of 75% and negative predictive value of 96%. When data were analyzed by position of salivary gland, a result was changed. Parotid gland showed an accuracy of 93%, sensitivity of 25% and specificity of 98%. Submandibular gland showed an accuracy, sensitivity and specificity of 100%, more accurate than parotid gland, due to difference in indication of FNAC, size and depth of lesion, incidence of disease and malignancy between both salivary glands.
Conclusion: FNAC had high specificity and high diagnostic accuracy in diagnosis of salivary gland malignancy both parotid and submandibular gland. It plays a useful role in planning management and evaluation of postoperative complication in patient with salivary gland mass.
References
2. Buley ID, Roskell DE. Fine-needle aspiration cytology in tumor diagnosis: uses and limitations. Clin Oncol (R Coll Radiol) 2000;12:166-71.
3. Zhang S, Bao R, Bagby J, et al. Fine needle aspiration of salivary glands: 5-year experience from a single academic center. Acta Cytol 2009;53:375-82.
4. Stewart CJ, MacKenzie K, McGarry GW, et al. Fine-needle aspiration cytology of salivary gland: a review of 341 cases. Diagn Cytopathol 2000;22:139-46.
5. Nguansangiam S, Jesdapatarakul S, Dhanarak N, et al. Accuracy of fine needle aspiration cytology of salivary gland lesions: routine diagnostic experience in Bangkok, Thailand. Asian Pac J Cancer Prev 2012;13:1583-8.
6. Ameli F, Baharoom A, Md Isa N, et al. Diagnostic challenges in fine needle aspiration cytology of salivary gland lesions. Malays J Pathol 2015;37:11-8.
7. Gupta R, Dewan D, Kumar D, et al. Fineneedle aspiration cytology (FNAC) of salivary gland lesions with histopathological correlation in a district hospital of Jammu region. Indian J Pathol Oncol 2016;3:32-7.
8. Gudmundsson JK, Ajan A, Abtahi J. The accuracy of fine-needle aspiration cytology for diagnosis of parotid gland masses: a clinicopathological study of 114 patients. J Appl Oral Sci 2016;24:561-7.
9. Bini F, Janhvi JB, Hiran KR. Reliability of Fine Needle Aspiration Cytology in salivary neoplasms: surgeon’s perspective. Amrita J Med 2014;10:23-9.
10. Hossain MA, Alam Z, Haque R, et al. Role of fine needle aspiration cytology in the preoperative diagnosis of malignancy in parotid and submandibular gland neoplasm. Bangladesh J Otorhinolaryngol 2013;19:110-8.
11. Venkateshwar P, Shalini T. Role of fine needle aspiration cytology in parotid tumours. Int J Adv Res 2015;3;1717-20.
12. Piccioni LO, Fabiano B, Gemma M, et al. Fine-needle aspiration cytology in the diagnosis of parotid lesions. Acta Otorhinolaryngol Ital 2011;31:1-4.
13. Singh Nanda KD, Mehta A, Nanda J. Fineneedle aspiration cytology: a reliable tool in the diagnosis of salivary gland lesions. J Oral Pathol Med 2012;41:106-12.
14. Qizilbash AH, Sianos J, Young JE, et al. Fine needle aspiration biopsy cytology of major salivary glands. Acta Cytol 1985;29:503-12.
15. Song IH, Song JS, Sung CO, et al. Accuracy of Core Needle Biopsy Versus Fine Needle Aspiration Cytology for Diagnosing Salivary Gland Tumors. J Pathol Transl Med 2015;49:136-43.
16. Jain R, Gupta R, Kudesia M, et al. Fine needle aspiration cytology in diagnosis of salivary gland lesions: A study with histologic comparison. Cytojournal 2013;10:5.
17. Omhare A, Singh SK, Nigam JS, et al. Cytohistopathological study of salivary gland lesions in bundelkhand region, uttar pradesh, India. Patholog Res Int 2014;2014:804265.
18. Mihashi H, Kawahara A, Kage M, et al. Comparison of preoperative fineneedle aspiration cytology diagnosis and histopathological diagnosis of salivary gland tumors. Kurume Med J 2006;53:23-7.
19. Iqbal M, Anwar K, Ihsanullah, et al. The diagnostic value of fine needle aspiration cytology in masses of the salivary glands. JPMI 2011;25:73-7.
20. Hughes JH, Volk EE, Wilbur DC, et al. Pitfalls in salivary gland fine-needle aspiration cytology: lessons from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology. Arch Pathol Lab Med 2005;129:26-31.
21. Parikh R, Mathai A, Parikh S, et al. Understanding and using sensitivity, specificity and predictive values. Indian J Ophthalmol 2008;56:45-50.
22. Laishram RS, Kumar KA, Pukhrambam GD, et al. Pattern of salivary gland tumors in Manipur, India: A 10 year study. South Asian J Cancer 2013;2:250-3.
23. Fassnacht W, Schmitz S, Weynand B, et al. Pitfalls in preoperative work-up of parotid gland tumours: 10-year series. B-ENT 2013;9:83-8.
24. Grimes DA, Schulz KF. Uses and abuses of screening tests. Lancet 2002;359:881-4.
25. Maxim LD, Niebo R, Utell MJ. Screening tests: a review with examples. Inhal Toxicol 2014;26:811-28.
26. Feinstein AJ, Alonso J, Yang SE, et al. Diagnostic Accuracy of Fine-Needle Aspiration for Parotid and Submandibular Gland Lesions. Otolaryngol Head Neck Surg 2016;155:431-6.
27. Liu CC, Jethwa AR, Khariwala SS, et al. Sensitivity, Specificity, and Posttest Probability of Parotid Fine-Needle Aspiration: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg 2016;154:9-23.
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ลิขสิทธิ์บทความเป็นของผู้เขียนบทความ แต่หากผลงานของท่านได้รับการพิจารณาตีพิมพ์ลงวารสารแพทย์เขต 4-5 จะคงไว้ซึ่งสิทธิ์ในการตีพิมพ์ครั้งแรกด้วยเหตุที่บทความจะปรากฎในวารสารที่เข้าถึงได้ จึงอนุญาตให้นำบทความในวารสารไปใช้ประโยชน์ได้ในเชิงวิชาการโดยจำเป็นต้องมีการอ้างอิงถึงชื่อวารสารอย่างถูกต้อง แต่ไม่อนุญาตให้นำไปใช้ในเชิงพาณิชย์
