Effect of Non-surgical Periodontal Therapy on Hemoglobin A1C in Patients with Type 2 Diabetes Mellitus
Keywords:
diabetes mellitus, periodontitis, HbA1C, oral epidemiologyAbstract
Objective: To assess effect of non-surgical periodontal therapy on HbA1C in patients with type 2 diabetes mellitus.
Methods: This study applied retrospective cohort data collection approach. The study retrospectively analyzed 220 Thai diabetic patients with diagnosis of periodontitis at Huayploo Hospital from October 2009 to August 2016. Patients were categorized as ‘studied group’ receiving full mouth scaling and root planing at least once during the study period and ‘referent group’ receiving none of periodontal therapy. Measurable confounders in this clinical contextincluded age, sex, body mass index, underlying diseases (hypertension, cardiovascular disease, cerebrovascular disease and chronic kidney disease), oral diabetic medication, insulin injection, duration of having diabetes mellitus, severity of periodontal disease and smoking. Effect of non-surgical periodontal therapy on HbA1C level in 6-year period was estimated by multilevel mixed-effects linear regression.
Results: In the first year (2010), HbA1C level of the studied group was 7.89% which was not significantly lower than that in the control group (7.93%), p=0.906. For the 6-year period, the regression model showed decrease of HbA1C by 0.1% per year in the studied group and 0.2% in the referent group after adjusting for aforementioned confounders, though not statistically significant (p=0.094). Random effect model showed statistical significance suggesting interpersonal difference in the effect of non-surgical periodontal therapy on HbA1C (p<0.001).
Conclusion: Non-statistically significant decrease in HbA1C level was identified in Type 2 diabetic patients receiving non-surgical periodontal therapy compared to that of patients without periodontal treatment. Effect of non-surgical periodontal therapy on HbA1C varies among different individuals.
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ลิขสิทธิ์บทความเป็นของผู้เขียนบทความ แต่หากผลงานของท่านได้รับการพิจารณาตีพิมพ์ลงวารสารแพทย์เขต 4-5 จะคงไว้ซึ่งสิทธิ์ในการตีพิมพ์ครั้งแรกด้วยเหตุที่บทความจะปรากฎในวารสารที่เข้าถึงได้ จึงอนุญาตให้นำบทความในวารสารไปใช้ประโยชน์ได้ในเชิงวิชาการโดยจำเป็นต้องมีการอ้างอิงถึงชื่อวารสารอย่างถูกต้อง แต่ไม่อนุญาตให้นำไปใช้ในเชิงพาณิชย์
