Factors Influencing to Treatments of Osteosarcoma Around the Knee

Abstract

Background : In the past conventional, standard treatment of osteosarcoma was amputation. Currently, the improvement in surgical techniques and new chemotherapy regimens made limb sparing procedure to become the new standard treatment. Limb sparing surgery has the comparable results as amputation. This study is to study the correlation of factor that influence the treatment options.

Objective : To study factors that influence decision of the limb sparing or amputation in osteosarcoma around the knee.

Material and method : 48 osteosarcoma patients from 2009 to 2012 have met our criteria to study about the factors that influence the treatment options. These factors are gender, age, tumor grade, percentage of tumor necrosis, location of tumor and pathological fracture.

Results : The study found that age more than 14 years old, high grade tumor and the presence of pathological fracture have increased risk for amputation (RR = 1.82, 4.25 and 3.7)