Drug Induced Stevens-Johnson Syndrome in Ratchaburi Hospital

Abstract

Objective: To identify clinical profile, causative drugs, treatment and outcome of Stevens – Johnson syndrome in Ratchaburi hospital

Material and method: A retrospective descriptive study in patients with Stevens - Johnson syndrome in Ratchaburi hospital from January 2010 to June 2011

Results: There were 13 patients with Stevens - Johnson syndrome with a mean age of 51. Allopurinol was the most common drug associated with Stevens - Johnson syndrome. Average interval between drugs ingestion and onset of symptoms was 16 days, with a range of 3 to 30 days. All patients had skin manifestations of erythematous maculopapular rashes and atypical target lesions with at least 2 mucosal involvements. All patients were treated with systemic corticosteroid and no patient was died.

Conclusion: Allopurinol was the most common drug associated with Stevens - Johnson syndrome in Ratchaburi hospital. All patients were treated with systemic corticosteroid and no patient was died.