Short-term Incidence of Ankle Edema after Switching from Amlodipine to Manidipine

Abstract

Calcium channel blocker (CCB) has a well-known side effect, an ankle edema, occurring 5-29%. It is one of the most important causes of patients’ poor compliance. In general, some practitioners switch from CCB to another class of antihypertensive agent but in fact, there are many patients who can continue CCB without side effects by simply changing to the other medications in the same class which have lower incidences of ankle edema. However, there is still no study to investigate the incidence of ankle edema alter switching from a high to a low-incidence CCB. We conducted a study in 19 hypertensive patients who have been treated at the out-patient division, Phra Chom Klao Hospital. Alter wash·out period, Manidipine 20 mg. was introduced for 4 weeks. An ankle edema, creatinine clearance (CCr), body weight (BW), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured before and alter this study period. The results showed that 3 patients or 15.8% of the sample had ankle edema. There was no significant difference of CCr (43.1 ± 18.4 vs 43.1 ± 16.8 ml/min, p > 0.05), BW (56.9 ± 9.7 vs 56.6 ± 9.7 kg, p > 0.05), SBP (142.4 ± 14.8 vs 143.4 ± 18.1 mm.Hg, p > 0.05), DBP (67.2 ± 9.4 vs 67.2 ± 10.7 mm.Hg, p > 0.05). There was no side effects in this study. In conclusion, the patients who suffered from Amlodipine-induced ankle edema could use Manidipine as an alternative safely.