Secondary Amenorrhea from Mosaicism (45,XO/46,XX)

Abstract

     A case report of 37 year’s old Mosaicism (45, X0/46, XX) patient who presented with Secondary amenorrhea for 11 years. She had psychological female and normal feminine body. Secondary sex characteristic, genital organ, height and mental were normal. General physical exam was within normal limit. The Ultrasound of pelvic organ finding was normal. The serum blood level : Serum 17 — β Oestradiol 12.0 pg/ml (normal 30.0 to 100), FSH 42.04 mIU/ml (5-20 mlU/ml), Prolactin 22 ng/ml (15-25 ng/ml), TSH 2.88 mlU/ml (0.27 - 4.20 mIU/ml). It was concluded that she was hypergonadotrophic amenorrhea. ln the other word, she had premature ovarian failure. Normal pelvic organ was seen by the diagnostic laparoscopy. The chromosome study was 45,X0/46, XX. The ratio was 30/70. Counseling the knowledge of premature ovarian failure and The combined cyclic hormone replacement therapy were given to her.