Baseline Level of Cardiac Troponin-I and CKMB in ESRD Patients at Ratchaburi Hospital and Effect of High Flux Dialysis on the Level

Abstract

          Objective:  To evaluate baseline levels of cardiac troponin-l, CKMB and effect of high flux dialysis on their levels in chronic hemodialysis patients at Ratchaburi hospital.

          Design:  A cross-sectional study was done on forty chronic hemodialysis ESRD patients.

          Material and method:  Blood samples were collected pre and post hemodialysis with high flux membrane for cardiac troponin-I and CKMB. Correlation of cardiac markers with gender, BMI, underlying DM and adequacy of hemodialysis(Kt/Vurea) were also done.

          Results: Level of pre-hemodialysis cardiac troponin-I was ranged from 0 to 0.59 ng/ml (mean = 0.0345 ± 0.1) and post-hemodialysis cardiac troponin-l was ranged from 0 to 0.49 ng/ml (mean = 0.035 ± 0.1). Pre-hemodialysis CKMB level was ranged from 0.04 to 35.7 ng/ml (mean = 4.03 ± 5.7) and post-hemodiaIysis CKMB was ranged from 0.03 to 34.8 mg/ml (mean = 4.11± 5.01). Pre and post hemodialysis level of cardiac troponin-l and CKMB were no statistically different. No statistically significant correlation of cardiac markers with gender, BMI, underlying DM and adequacy of hemodialysis (Kt/Vurea)

          Conclusion: Baseline cardiac troponin-I and CKMB were below significant level in the majority of our patients. High flux dialysis had no significant effect on cardiac troponin-l and CKMB level.