Reduction of Perinatal HIV-1 Transmission with Short Course Zidovudine Prophylaxis in Nakornpathom Hospital, Thailand.

Abstract

A prospective open labeled study was desinged to evaluate the efficacy of short course prophylactic zidovudine (ZDV) use in late prenatal-perinataI-7 days postnatal regimen and perinatal-6 weeks neonatal regimen. One hundred fifteen asymptomatic HIV-I infected pregnant women were enrolled. Breast feeding was not allowed. The perinatal HIV-I transmission rate was reduced from 20.63%  ( ) before ZDV use to 7.69% (  ) in late prenatal perinatal - 7 days postnatal regimen significantly (p < 0.05) and reduced to 13.5% ()  in perinatal 6 weeks neonatal ZDV regimen not significantly (p > 0.05). Gender, preterm, mode of delivery and birth weight did not influence the perinatal transmission.