Mycosis Fungoides in Pregnancy

A Case Report with Ultrastructural Feature

Abstract

A 26 - year - old Thai female, 2 months of pregnancy, presented with asymptomatic large dry scaly erythematous patches with wrinkle surface on the back, abdomen and lower extremities. The lesions persisted and were not improved by many topical treatments.

Histopathology revealed epidermotrophism, single cell with halo and Electron microscope showed Pautrier microabscess with Lützner cell in epidermis and dermis. This finding is consistent withmycosis fungoides (MF) in pregnancy. The lesions did not flare up during her pregnancy until she had anormal delivery of a normal healthy new born. Her infant weighed 3,200 grams and did not showcutaneous lesion of mycosis fungoides. After delivery, she was treated with systemic photochemotherapy (PUVA) with a good result. The cutaneous lesions were clear within 6 months of treatment with no complications, and no relapse of disease after 2 years.