The Effect of Vitamin K Injection in Cirrhosis with Prolong Prothrombin Time : 1 - Year Prospective Study.

Abstract

          A randomized controlled trial to study the effectiveness of vitamin K injection in liver cirrhosis with prolong prothrombin time was conducted in Nakhonnayok hospital during June 1994 to May 1995. Of 65 patients enrolled in the study. Five patients were excluded by exclusion criteria due to developed upper gastrointestinal bleeding. They were randomly allocated to recieve vitamin K (10 mg/day) or placebo for 3 days. Each group has 30 patients and was checked prothrombin time after complete injection and one week later. No significant changes of prothrombin time after vitamin K administration and placebo group. In conclusion vitamin K injection for correction of prothrombin time in cirrhosis patient is not beneficial.