The Effect of Photodynamic Therapy for Chronic Periodontitis
Keywords:
photodynamic therapy, chronic periodontitisAbstract
Periodontitis is the chronic inflammation of supporting structures of teeth.The objective of periodontal therapy is to reduce the periodontopathic bacteria. Scaling and root planing are considered as the gold standard techniques of periodontal therapy, but their effectiveness can be compromised by deep pockets, complex root anatomy. Phototherapy using low level lasers is called photodynamic therapy. Photodynamic therapy targets the bacteria without damaging the host tissue. The aim of this review is to describe about the photodynamic therapy and its uses and evidences in periodontics.
References
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10. Soukos NS, Goodson MJ. Photodynamic therapy in the control of oral biofilms. Periodontology 2000. 2011; 55: 143–66.
11. Kikuchi T, Mogi M, Okabe I, et al. Adjunctive application of antimicrobial photodynamic therapy in nonsurgical periodontal treatment: A review of literature. Int J Mol Sci. 2015; 16(10): 24111-26. doi: 10.3390/ijms161024111
12. Laljyothi S, Ambili R, Abraham S, et al. An Insight in to Photodynamic Therapy. Acta Scientific Dental Sciences. 2018; 2(6): 71-8.
13. Usacheva MN, Teichert MC, Biel MA. Comparison of the methylene blue and toluidine blue photo bactericidal efficacy against gram-positive and gram-negative microorganisms. Lasers Surg Med. 2001; 29(2): 165-73. Doi: 10.1002/lsm.1105
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15. Sigusch BW, Pfitzner A, Albrecht V, et al. Efficacy of photodynamic therapy on inflammatory signs and two selected periodontopathogenic species in a beagle dog model. J Periodontol. 2005; 76(7): 1100-5. doi: 10.1902/jop.2005.76.7.1100.
16. Andersen R, Loebel N, Hammond D, et al. Treatment of periodontal disease by photodisinfection compared to scaling and root planing. J Clin Dent. 2007; 18(2): 34-8.
17. Chondros P, Nikolidakis D, Christodoulides N , et al. Photodynamic Therapy as an Adjunctto Non-Surgical Periodontal Treatment: A Randomized, Controlled Clinical Trial. J Periodontol. 2008; 79(9): 1638-44. doi: 10.1007/s10103-008-0565-z
18. Braun A, Dehn C, Krause F, et al. Short-term clinical effects of adjunctive antimicrobial photodynamic therapy in periodontal treatment: A randomized clinical trial. J Clin Periodontol. 2008; 35(10): 877-84. doi: 10.1111/j.1600-051X.2008.01303.x.
19. Polansky R, Haas M, Heschl A, et al. Clinical effectiveness of photodynamic therapy in the treatment of periodontitis. J Clin Periodontol 2009; 36(7): 575-80. doi: 10.1111/j.1600-051x.2009.01412.x.
20. Lulic M, Gorog IL, Salvi GE, et al. One-year outcome repeated adjunctive photodynamic therapy during periodontal maintenance: A proof-of-principle randomized-controlled clinical trial. J Clin Periodontol. 2009; 36(8): 661-6. doi: 10.1111/j.1600-051X.2009.01432.x.
21. Pourabbas R, Kashefimehr A, Rahmanpour N, et al. Effects of photodynamic therapy on clinical and gingival crevicular fluid inflammatory biomarkers in chronic periodontitis: A split-mouth randomized clinical trial. J Periodontol. 2014; 85(9): 1222-9. doi: 10.1902/jop.2014.130464
22. Betsy J, Prasanth CS, Baiju KV, et al. Efficacy of antimicrobial photodynamic therapy in the management of chronic periodontitis: A randomized controlled clinical trial. J Clin Periodontol. 2014; 41(6): 573-81. doi: 10.1111/jcpe.12249
23. Bundidpun P, Srisuwantha R, Laosrisin N. Clinical effects of photodynamic therapy as an adjunct to full-mouth ultrasonic scaling and root planing in treatment of chronic periodontitis. Laser Ther. 2017; 27(1): 33-9. doi: 10.5978/islsm.18-OR-03
24. Husejnagic S, LettnernS, Laky M, et al. Photoactivated disinfection in periodontal treatment: A randomized controlled clinical split-mouth trial. J Periodontol. 2019; 00: 1–10. doi: 10.1002/JPER.18-0576.
25. Giannelli M, Lasagni M, Bani D. Photonic Therapy in Periodontal Diseases an Overview with Appraisal of the Literature and Reasoned Treatment Recommendations. ijms. 2019; 20(4741): 1-25.
26. Sculean A, Aoki A, Romanos G, et al. Is photodynamic therapy an effective treatment for periodontal and peri-implant infections. Dent Clin North Am. 2015; 59(4): 831–58. doi: 10.1016/j.cden.2015.06.008.
27. Woodruff LD, Bounkeo JM, Brannnon WM, et al. The efficacy of laser therapy in wound repair: A metaanalysis of the literature. Photomed Laser Surg. 2004; 22(3): 241-7. doi: 10.1089/1549541041438623.
28. Chambrone L, Wang HL, Romanos GE. Antimicrobial photodynamic therapy for the treatment of periodontitis and peri-implantitis: An American Academy of Periodontology best evidence review. J Periodontol. 2018; 89(7): 783–803. doi: 10.1902/jop.2017.170172.
29. Fontana CR, Abernethy AD, Som S, et al. The antibacterial effect of photodynamic therapy in dental plaque-derived biofilms. J Periodontal Res. 2009; 44(6): 751–9. doi: 10.1111/j.1600-0765.2008.01187.x
2. Drisko CH. Nonsurgical periodontal therapy. Periodontology 2000. 2001; 25: 77–88. doi: 10.1034/j.1600-0757.2001.22250106.x.
3. Pihlstrom BL, McHugh RB, Oliphant TH, et al. Comparison of surgical and nonsurgical treatment of periodontal disease. A review of current studies and additional results after 6 1/2 years. J Clin Periodontol. 1983; 10(5): 524–41. doi: 10.1111/j.1600-051x.1983.tb02182.x.
4. Badersten A, Nilveus R, Egelberg J. Effect of nonsurgicalperiodontal therapy. I. Moderately advanced periodontitis. J Clin Periodontol. 1981; 8(1): 57-72. doi: 10.1111/j.1600-051x.1981.tb02024.x.
5. Cugini MA, Haffajee AD, Smith C, et al. The effect of scaling and root planing on the clinical and microbiological parameters of periodontal diseases: 12-month results. J Clin Periodontol. 2000; 27(1): 30-6. doi: 10.1034/j.1600-051x.2000.027001030.x
6. Umeda M, Takeuchi Y, Noguchi K, et al. Effects of nonsurgical periodontal therapy on the microbiota. Periodontol 2000. 2004; 36: 98-120. doi: 10.1111/j.1600-0757.2004.03675.x.
7. Heitz-Mayfield LJA. Systemic antibiotics in periodontal therapy. Aust Dent J. 2009; 54(Suppl1): S96–S101. doi: 10.1111/j.1834-7819.2009.01147.x.
8. Greenstein G, Polson A. The role of local drug delivery in the management of periodontal diseases: A comprehensive review. J Periodontol. 1998; 69(5): 507-20.
9. Thomas GV, Saumya J, Sreejith CK, et al. Photodynamic Therapy - A New Ray of Hope in Periodontics. IJCMR. 2017; 4(2): 2454-7379.
10. Soukos NS, Goodson MJ. Photodynamic therapy in the control of oral biofilms. Periodontology 2000. 2011; 55: 143–66.
11. Kikuchi T, Mogi M, Okabe I, et al. Adjunctive application of antimicrobial photodynamic therapy in nonsurgical periodontal treatment: A review of literature. Int J Mol Sci. 2015; 16(10): 24111-26. doi: 10.3390/ijms161024111
12. Laljyothi S, Ambili R, Abraham S, et al. An Insight in to Photodynamic Therapy. Acta Scientific Dental Sciences. 2018; 2(6): 71-8.
13. Usacheva MN, Teichert MC, Biel MA. Comparison of the methylene blue and toluidine blue photo bactericidal efficacy against gram-positive and gram-negative microorganisms. Lasers Surg Med. 2001; 29(2): 165-73. Doi: 10.1002/lsm.1105
14. Dobson J, Wilson M . Sensitization of oral bacteria in biofilms to killing by light from a low-power laser. Arch Oral Biol. 1992; 37(11): 883-7. doi: 10.1016/0003-9969(92)90058-g.
15. Sigusch BW, Pfitzner A, Albrecht V, et al. Efficacy of photodynamic therapy on inflammatory signs and two selected periodontopathogenic species in a beagle dog model. J Periodontol. 2005; 76(7): 1100-5. doi: 10.1902/jop.2005.76.7.1100.
16. Andersen R, Loebel N, Hammond D, et al. Treatment of periodontal disease by photodisinfection compared to scaling and root planing. J Clin Dent. 2007; 18(2): 34-8.
17. Chondros P, Nikolidakis D, Christodoulides N , et al. Photodynamic Therapy as an Adjunctto Non-Surgical Periodontal Treatment: A Randomized, Controlled Clinical Trial. J Periodontol. 2008; 79(9): 1638-44. doi: 10.1007/s10103-008-0565-z
18. Braun A, Dehn C, Krause F, et al. Short-term clinical effects of adjunctive antimicrobial photodynamic therapy in periodontal treatment: A randomized clinical trial. J Clin Periodontol. 2008; 35(10): 877-84. doi: 10.1111/j.1600-051X.2008.01303.x.
19. Polansky R, Haas M, Heschl A, et al. Clinical effectiveness of photodynamic therapy in the treatment of periodontitis. J Clin Periodontol 2009; 36(7): 575-80. doi: 10.1111/j.1600-051x.2009.01412.x.
20. Lulic M, Gorog IL, Salvi GE, et al. One-year outcome repeated adjunctive photodynamic therapy during periodontal maintenance: A proof-of-principle randomized-controlled clinical trial. J Clin Periodontol. 2009; 36(8): 661-6. doi: 10.1111/j.1600-051X.2009.01432.x.
21. Pourabbas R, Kashefimehr A, Rahmanpour N, et al. Effects of photodynamic therapy on clinical and gingival crevicular fluid inflammatory biomarkers in chronic periodontitis: A split-mouth randomized clinical trial. J Periodontol. 2014; 85(9): 1222-9. doi: 10.1902/jop.2014.130464
22. Betsy J, Prasanth CS, Baiju KV, et al. Efficacy of antimicrobial photodynamic therapy in the management of chronic periodontitis: A randomized controlled clinical trial. J Clin Periodontol. 2014; 41(6): 573-81. doi: 10.1111/jcpe.12249
23. Bundidpun P, Srisuwantha R, Laosrisin N. Clinical effects of photodynamic therapy as an adjunct to full-mouth ultrasonic scaling and root planing in treatment of chronic periodontitis. Laser Ther. 2017; 27(1): 33-9. doi: 10.5978/islsm.18-OR-03
24. Husejnagic S, LettnernS, Laky M, et al. Photoactivated disinfection in periodontal treatment: A randomized controlled clinical split-mouth trial. J Periodontol. 2019; 00: 1–10. doi: 10.1002/JPER.18-0576.
25. Giannelli M, Lasagni M, Bani D. Photonic Therapy in Periodontal Diseases an Overview with Appraisal of the Literature and Reasoned Treatment Recommendations. ijms. 2019; 20(4741): 1-25.
26. Sculean A, Aoki A, Romanos G, et al. Is photodynamic therapy an effective treatment for periodontal and peri-implant infections. Dent Clin North Am. 2015; 59(4): 831–58. doi: 10.1016/j.cden.2015.06.008.
27. Woodruff LD, Bounkeo JM, Brannnon WM, et al. The efficacy of laser therapy in wound repair: A metaanalysis of the literature. Photomed Laser Surg. 2004; 22(3): 241-7. doi: 10.1089/1549541041438623.
28. Chambrone L, Wang HL, Romanos GE. Antimicrobial photodynamic therapy for the treatment of periodontitis and peri-implantitis: An American Academy of Periodontology best evidence review. J Periodontol. 2018; 89(7): 783–803. doi: 10.1902/jop.2017.170172.
29. Fontana CR, Abernethy AD, Som S, et al. The antibacterial effect of photodynamic therapy in dental plaque-derived biofilms. J Periodontal Res. 2009; 44(6): 751–9. doi: 10.1111/j.1600-0765.2008.01187.x
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2021-03-24
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Wongakeugsorn T. The Effect of Photodynamic Therapy for Chronic Periodontitis. Reg 4-5 Med J [internet]. 2021 Mar. 24 [cited 2025 Dec. 30];40(1). available from: https://he02.tci-thaijo.org/index.php/reg45/article/view/250095
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