The Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Advance Colorectal Cancer in Ratchaburi Hospital
Keywords:
colorectal cancer, complete blood count, neutrophil-to-lymphocyte ratioAbstract
Objective: Cancer-associated inflammation has a critical role in the pathogenesis and prognosis of cancers. Previous studies of the microenvironment of cancer supported the relationship between inflammation and cancer. Evidences have shown that neutrophil-to-lymphocyte ratio (NLR) is related to prognosis in many cancers. This study investigated the relationship between pre-treatment NLR and clinical outcome in advance stage colon cancer patients in Ratchaburi Hospital.
Methods: A total of 222 patients with advance colon cancer diagnosed from 2017–2019 in Ratchaburi Hospital were included in this retrospective study. Completed demographic data including age, ECOG, tumor grade, tumor stage, complete blood count, blood chemistry, and serum biochemical profile were collected. We analyzed the association of pretreatment NLR with progression free survival (PFS).
Results: We defined two groups consisting of 86 patients with NLR ≥3 (38.7%) and 136 patients with NLR <3 (60.3%). Mean age for both groups were 62.33 ± 11.65 years. In univariate analysis, the NLR ≥3 patients group were significantly associated with an higher incident of recurrence (HR 1.71; 95% CI 1.27–2.29; p < .001) and it remained significant in multivariate analysis (HR 1.52; 95% CI 1.1–2.1; p = .011). Patients with NLR ≥3 had median PFS 8.22 months and patients with NLR <3 had median PFS 13.1 months (p = .04).
Conclusion: This study suggests that pre-treatment NLR may be associated with progression free survival in patients with advance colorectal cancer. NLR has the advantage of wide availability and economically clinical practice.
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ลิขสิทธิ์บทความเป็นของผู้เขียนบทความ แต่หากผลงานของท่านได้รับการพิจารณาตีพิมพ์ลงวารสารแพทย์เขต 4-5 จะคงไว้ซึ่งสิทธิ์ในการตีพิมพ์ครั้งแรกด้วยเหตุที่บทความจะปรากฎในวารสารที่เข้าถึงได้ จึงอนุญาตให้นำบทความในวารสารไปใช้ประโยชน์ได้ในเชิงวิชาการโดยจำเป็นต้องมีการอ้างอิงถึงชื่อวารสารอย่างถูกต้อง แต่ไม่อนุญาตให้นำไปใช้ในเชิงพาณิชย์
