Comparing the Effect of Intravenous Parecoxib for Acute Pain Management Before and After of Total Abdominal Hysterectomy
Keywords:
parecoxib, abdominal hysterectomy, postoperative painAbstract
Objective: To compare the effect of intravenous parecoxib administered before and after total abdominal hysterectomy for pain management.
Methods: The present study was conducted as a randomized controlled trial. Data were collected from patients, scheduled for abdominal hysterectomy under spinal anesthesia with intrathecal morphine, at Makarak Hospital, Kanchanaburi Province, between June 2023 and February 2024. Patients were randomly devided into 2 groups. Group A, 28 cases, received 40 mg of parecoxib intravenously 1 hour before surgery and group B, 28 cases, received 40 mg of parecoxib intravenously 2 hours after surgery. The outcome measurements included recorded visual analogue pain score (VAS) at 6, 12, 18, and 24 hours at rest and during movement after surgery; tramadol consumption, nausea, vomiting, pruritus, and patients’ satisfaction.
Results: No significant differences were found in age, body weight, height, body mass index (BMI), type of disease, type of operation, type of incision, surgical time, incisional length, blood loss and specimen weight between the 2 groups. Pain score at rest or during movement at 6, 12, 18, and 24 hours; post-operative tramadol consumption; nausea; vomiting; pruritus; and patients’ satisfaction were also not significantly different between the 2 groups.
Conclusion: The timing of intravenous parecoxib administration before and after total abdominal hysterectomy had no clinically significant difference in postoperative pain effect among all subjects who underwent spinal anesthesia with intrathecal morphine.
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ลิขสิทธิ์บทความเป็นของผู้เขียนบทความ แต่หากผลงานของท่านได้รับการพิจารณาตีพิมพ์ลงวารสารแพทย์เขต 4-5 จะคงไว้ซึ่งสิทธิ์ในการตีพิมพ์ครั้งแรกด้วยเหตุที่บทความจะปรากฎในวารสารที่เข้าถึงได้ จึงอนุญาตให้นำบทความในวารสารไปใช้ประโยชน์ได้ในเชิงวิชาการโดยจำเป็นต้องมีการอ้างอิงถึงชื่อวารสารอย่างถูกต้อง แต่ไม่อนุญาตให้นำไปใช้ในเชิงพาณิชย์
