The Neuroprotective Effect of Bacopa monnieri against Pilocarpine Induced Status Epilepticus in Rats
Keywords:
Status epilepticus (SE); seizure; pilocarpine; Bacopa monnieri (Brahmi); learning and memory; hippocampusAbstract
Objective: To examine the therapeutic potential of Brahmi extract as a neuroprotective treatment for status epilepticus (SE).
Methods: After the oral administration of 160 mg/kg BM extract for 2 weeks, SE was induced by an i.p. injection of pilocarpine, and spatial learning and memory were tested on the next day. After the behavioral testing, all animals were sacrificed, and the brains were removed for histological examination to determine the amount of surviving neurons in the hippocampal subregions.
Results: SE caused spatial learning and memory impairment, and significant reduction of surviving neurons in all subregions of the hippocampus. Pre-treatment with BM extract could attenuate the spatial learning and memory deficit and reduced neuronal death in all subregions of the hippocampus.
Conclusion: BM extract demonstrated the neuroprotective effect against SE induced spatial learning and memory deficit and neuronal death in the hippocampus.
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following conditions:
Copyright Transfer
In submitting a manuscript, the authors acknowledge that the work will become the copyrighted property of Siriraj Medical Journal upon publication.
License
Articles are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). This license allows for the sharing of the work for non-commercial purposes with proper attribution to the authors and the journal. However, it does not permit modifications or the creation of derivative works.
Sharing and Access
Authors are encouraged to share their article on their personal or institutional websites and through other non-commercial platforms. Doing so can increase readership and citations.