The Neuroprotective Effect of Bacopa monnieri against Pilocarpine Induced Status Epilepticus in Rats

Authors

  • Thanaporn Semphuet Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Atthaporn Boongird Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400
  • Mayuree H. Tantisira Faculty of Pharmaceutical Sciences, Burapha University, ChonBuri 20131
  • Kanokwan Tiloksakulchai Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Sompol Tapechum Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Narawut Pakaprot Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700

Keywords:

Status epilepticus (SE); seizure; pilocarpine; Bacopa monnieri (Brahmi); learning and memory; hippocampus

Abstract

Objective: To examine the therapeutic potential of Brahmi extract as a neuroprotective treatment for status epilepticus (SE).
Methods: After the oral administration of 160 mg/kg BM extract for 2 weeks, SE was induced by an i.p. injection of pilocarpine, and spatial learning and memory were tested on the next day. After the behavioral testing, all animals were sacrificed, and the brains were removed for histological examination to determine the amount of surviving neurons in the hippocampal subregions.
Results: SE caused spatial learning and memory impairment, and significant reduction of surviving neurons in all subregions of the hippocampus. Pre-treatment with BM extract could attenuate the spatial learning and memory deficit and reduced neuronal death in all subregions of the hippocampus.
Conclusion: BM extract demonstrated the neuroprotective effect against SE induced spatial learning and memory deficit and neuronal death in the hippocampus.

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Published

20-12-2017

How to Cite

Semphuet, T., Boongird, A., Tantisira, M. H., Tiloksakulchai, K., Tapechum, S., & Pakaprot, N. (2017). The Neuroprotective Effect of Bacopa monnieri against Pilocarpine Induced Status Epilepticus in Rats. Siriraj Medical Journal, 69(6), 345–350. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/106173

Issue

Vol. 69 No. 6 (2017): November-December

Section

Original Article

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