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Objective: To evaluate the relationships between mammographic and ultrasound features and histological grades of invasive ductal carcinoma using the terminology of the fifth edition of Breast Imaging Reporting and Data System
Methods: Mammographic and ultrasound features of invasive breast carcinomas diagnosed in 104 consecutive women between January 2011 and August 2014 were retrospectively reviewed, described according to the BI-RADS
lexicon, and correlated with histological tumor grade according to the Nottingham histologic scoring system.
Results: 104 invasive ductal carcinomas were graded histologically as follows: grade 1, 12.5%; grade 2, 50%; and grade 3, 37.5%. In multivariate analyses, mammographically identified oval or round shape of masses and indistinct
margin were significantly associated with grade 3 tumors (p < 0.05). In addition, ultrasound-identified microlobulated margin was significantly associated (p = 0.013) with grade 3 tumors. In contrast, mammographically identified
spiculated margin and ultrasound-identified posterior shadowing occurred significantly more frequently in grade 1 tumors (p < 0.05).
Conclusion: Mammographic and ultrasound features are effective predictors of histologic tumor grade of breast cancer.
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