Impact of 18F-FDG PET/CT Scan on Management of Non-small Cell Lung Cancer Patients in Contexts of University-Based Hospital in Thailand

Authors

  • Achiraya Teyateeti Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol Unversity, Bangkok 10700
  • Pawana Pusuwan Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol Unversity, Bangkok 10700
  • Ajalaya Teyateeti Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol Unversity, Bangkok 10700

Keywords:

Public Open Spaces, Use Patterns, Characteristics of Public Open Spaces, Trang Town’s commercial areas

Abstract

Objective: To determine the impact of Fluorine-18 fluorodeoxy glucose (18F-FDG) positron emission tomography with computed tomography (PET/CT scan) on management of non-small cell lung cancer (NSCLC) in contexts
of university-based hospital in Thailand where most patients were in advanced disease and conventional imaging (CI) had previously been done.
Methods: Between December 2006 to December 2014, PET/CT scan and CI - e.g. chest and upper abdominal CT scan and bone scintigraphy of 120 pathologically proven NSCLC patients were independently reviewed. Stagings based
on CI and PET/CT scan were evaluated. Proposed treatment plan based on CI and given treatment based on PET/ CT scan were compared in patients whose medical records were available. Impact of PET/CT scan on management
was categorized into inter-modality and intra-modality treatment change – i.e. change in radiation fields.
Results: Of 120 NSCLC patients, PET/CT scans were performed for initial staging (INS) in 60 patients, posttreatment evaluation (PTE) in 41 patients and restaging at time of recurrence or progression (RR) in 19 patients.
PET/CT scan changed the disease status in 38 patients (31.7%). Changes to more advanced and less advanced disease were found in 26 patients (11 INS, 8 PTE and 7 RR patients) and 12 patients (3 INS, 6 PTE and 3 RR patients),
respectively. Among 83 patients with available proposed treatment plan, inter-modality treatment changes were observed in 19 patients (22.9%). Changes were more frequent in setting of PTE and RR (14/19 patients; 73.7%). The
most common changes were toward palliative chemotherapy (15/19 patients, 78.9%) owing to unexpected distant metastasis. Among 43 patients who received radiation therapy, changes in radiation approach were found in 18
patients (41.9%), mostly due to positive or negative lymph node (LN) metastasis.
Conclusion: PET/CT scan has considerable impact on staging and both inter-modality and intra-modality treatment change in NSCLC patients in all settings – INS, PTE and RR even with the presence of CI. Therefore, PET/CT scan
should be considered for staging and guiding the multidisciplinary treatment.

Downloads

Published

07-06-2018

How to Cite

Teyateeti, A., Pusuwan, P., & Teyateeti, A. (2018). Impact of 18F-FDG PET/CT Scan on Management of Non-small Cell Lung Cancer Patients in Contexts of University-Based Hospital in Thailand. Siriraj Medical Journal, 70(2), 169–174. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/127517

Issue

Vol. 70 No. 2 (2018): March-April

Section

Original Article

License

Authors who publish with this journal agree to the following conditions:

Copyright Transfer

In submitting a manuscript, the authors acknowledge that the work will become the copyrighted property of Siriraj Medical Journal upon publication.

License

 Articles are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). This license allows for the sharing of the work for non-commercial purposes with proper attribution to the authors and the journal. However, it does not permit modifications or the creation of derivative works.

Sharing and Access

Authors are encouraged to share their article on their personal or institutional websites and through other non-commercial platforms. Doing so can increase readership and citations.