Posaconazole Induced Diffuse Lentigines: A Case Report

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Kittipoom Chinhiran
Charussri Leeyaphan


Objective: To report a case of posaconazole induced diffuse lentigines.
Case presentation: A 57-year-old Thai male with acute promyelocytic leukemia who received chemotherapy and antifungal drug prophylaxis then appeared abruptly generalized multiple discrete well-defined brownish macules on
face, lips, trunk, back, both arms, forearms, both thighs, legs, both palms and soles about eight days after received posaconazole.
Conclusion: Multiple lentigines could be found in patients who received immunosuppression or immunomodulation, and antifungal drugs such as voriconazole.


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Chinhiran, K., & Leeyaphan, C. (2018). Posaconazole Induced Diffuse Lentigines: A Case Report. Siriraj Medical Journal, 70(2), 182–183. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/127526
Case Report