Serum Neuropeptide Y and Leptin Levels compared between Non-pregnant and Pregnant Women in Overall, Non-obese, and Obese Subjects

Authors

  • Chantacha Sitticharoon Department of Physiology
  • Roongrit Klinjampa Department of Physiology
  • Xaynaly Souvannavong-Vilivong Department of Physiology
  • Saimai Chatree Department of Physiology
  • Peerada Boonpuan Department of Biopharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Burapha University
  • Chanakarn Sripong Department of Physiology
  • Nay Chi Nway Department of Physiology, University of Medicine 1, Yangon, 11041
  • Tripop Lertbunnaphong Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700

Keywords:

Neuropeptide Y; Leptin; non-pregnant; pregnant women

Abstract

Objective: The primary objective of this study was to compare serum NPY and leptin levels between non-pregnant and pregnant women in overall, non-obese, and obese subjects. The secondary objective was to compare these
peptides between non-obese and obese pregnant women.
Methods: Fasting venous blood was collected from non-pregnant women before open abdominal surgery and from pregnant women when admitted to the delivery room during the latent phase of labor.
Results: There were 12 non-obese and 14 obese subjects in the non-pregnant group and 9 non-obese and 30 obese subjects in the pregnant group. Systolic blood pressure (SBP) was comparable, but heart rate (HR) was higher in pregnant
compared to non-pregnant women. Mean±S.E.M serum NPY levels were lower in the pregnant than in the non-pregnant group in overall (0.54±0.02 and 1.34±0.08, respectively), non-obese (0.53±0.05 and 1.23±0.14, respectively), and obese
(0.54±0.03 and 1.43±0.09, respectively) subjects (p<0.01 for all), but these were comparable between obese and nonobese pregnant subjects. Serum NPY was positively correlated with SBP (R=0.281, p<0.05), but negatively correlated
with HR (R=-0.324, p<0.01). Serum leptin levels were not different between pregnant and non-pregnant groups, but were significantly higher in obese than non-obese pregnant subjects (p<0.001). Serum leptin levels were positively
correlated with body weight, BMI, waist and hip circumferences in overall and pregnant subjects (p<0.001 all).
Conclusion: In pregnancy, decreased NPY levels might be associated with inhibition of SBP rising as well as increased HR. Leptin levels might not be associated with pregnancy, but associated mainly with obesity.

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Published

20-06-2018

How to Cite

Sitticharoon, C., Klinjampa, R., Souvannavong-Vilivong, X., Chatree, S., Boonpuan, P., Sripong, C., Chi Nway, N., & Lertbunnaphong, T. (2018). Serum Neuropeptide Y and Leptin Levels compared between Non-pregnant and Pregnant Women in Overall, Non-obese, and Obese Subjects. Siriraj Medical Journal, 70(3), 204–212. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/129611

Issue

Vol. 70 No. 3 (2018): May-June

Section

Original Article

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