The Contamination of Intravenous Fluid by Felt-Tip Marking Pen Ink: A Pilot Study
Keywords:
Ink; marking pen ink; pilot studyAbstract
Objective: The practice of writing directly on infusion bags with felt-tip marking pen was suggested to cause
contaminations. Recommendation against such practice has been published by manufacturers and health care
authorities. A chromatography-based laboratory experiment was conducted to substantiate the possibility of ink
constituents permeation through Polyvinylchloride (PVC) infusion bag.
Methods: A Viaflex® intravenous infusion bag was marked with a blue Artline® marking pen ink. Fluid samples
were obtained at different time intervals and tested for any contaminations. A gas chromatography with mass
spectrometry capability system was used to analyse fluid samples from infusion bag.
Results: Five fluid samples were obtained from the infusion bag at 0, 10, 30, 60, 120 minutes after ink exposure.
Chromatograms from each sample were compared with a chromatogram from “blank” intravenous solution. There
appeared to be no chromatographic evidence of ink constituents present in all intravenous fluid samples.
Conclusion: The practice of writing directly on Viaflex® infusion bags with a felt-tip marking pen has not resulted
in contamination of intravenous fluid by ink constituents.
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