Cefoxitin Plus Doxycycline Versus Clindamycin Plus Gentamicin in Hospitalized Pelvic Inflammatory Disease Patients: An Experience from A Tertiary Hospital

Authors

  • Pattraporn Chera-aree Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Chenchit Chayachinda Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Suvimol Niyomnaitham Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Witchuda Kamolvit Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University and Department of Microbiology, Tumour and Cell Biology, Division of Clinical Microbiology, Karolinska Institutet and Karolinska University Hospital, 17176 Stockholm, Sweden.

Keywords:

Antibiotics; cefoxitin plus doxycycline; clindamycin plus gentamicin; pelvic inflammatory disease; tubo-ovarian abscess

Abstract

Objective: To compare length of hospital stay (LOS) and surgical rate in patients hospitalized with pelvic inflammatory disease (PID) who received either cefoxitin plus doxycycline regimen or clindamycin plus gentamicin regimen.
Methods: Medical records of patients hospitalized with PID from 2004 to 2011 were reviewed. Study population was women aged 14-40 years old who had a first-time, admitted diagnosis and a discharged diagnosis of PID. Patients who had prior hysterectomy, bilateral salpingectomy and were not sexually active were excluded. The patients received either intravenous cefoxitin (2 grams every 6 hours) plus oral doxycycline (100 mg twice a day) regimen or intravenous clindamycin (900 mg every 8 hours) plus gentamicin (240 mg once daily) regimen. Outcomes of interest were LOS and surgical rate.
Results: Of 252 eligible participants, 141 (55.95%) received cefoxitin plus doxycycline and 111 (44.05%) received clindamycin plus gentamicin. The patients receiving cefoxitin plus doxyclycline had statistically significant lower age and less number of cases of tubo-ovarian abscess (TOA) (P<0.05). Logistic regression showed the similar LOS and surgical rate in both groups after adjusted with age and TOA. No severe adverse effect was identified in both regimens.
Conclusion: Cefoxitin plus doxycycline regimen appears as effective as clindamycin plus gentamicin regimen for treating hospitalized PID patients in terms of LOS, surgical rate and safety profile.

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Published

27-12-2018

How to Cite

Chera-aree, P., Chayachinda, C., Niyomnaitham, S., & Kamolvit, W. (2018). Cefoxitin Plus Doxycycline Versus Clindamycin Plus Gentamicin in Hospitalized Pelvic Inflammatory Disease Patients: An Experience from A Tertiary Hospital. Siriraj Medical Journal, 70(6), 479–483. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/163137

Issue

Vol. 70 No. 6 (2018): November-December

Section

Original Article

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