Predictive Factors for Survival Outcomes of High-Risk Febrile Neutropenic Patients: a 3-Year Study at a Single Center in Thailand

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Wannaphorn Rotchanapanya
http://orcid.org/0000-0003-4679-8647
Weerapat Owattanapanich
http://orcid.org/0000-0002-1262-2005
Nonlawan Chueamuangphan
http://orcid.org/0000-0002-8419-5129

Abstract

Objective: This study aimed to identify the risk factors associated with mortality in febrile neutropenic patients.  
Methods: This 3-year, single center, retrospective, observational study was conducted at Chiangrai Prachanukroh Hospital, Chiangrai Province, Thailand. The inclusion criteria consisted of a patient age of over 15 years and a diagnosis of febrile neutropenia. 
Results: Most of the 303 febrile neutropenic inpatients had a Multinational Association for Supportive Care in Cancer (MASCC) risk score < 21. The median length of stay was 6 days (interquartile range: 4-11 days). During 30 days of admission, 24.8% of the patients succumbed. In a univariate analysis, patients receiving G-CSF, the post-chemotherapy-related group, patients with MASCC score > 16, and patients admitted in private had significantly higher survival rate. In a multivariate analysis, a MASCC score ≤ 16 and non-chemotherapy-related groups were associated with an increased mortality risk.
Conclusion: The 30-day survival rate of febrile neutropenic patients in Thailand is seventy-five percent. Low MASCC score and non-chemotherapy-related neutropenia are associated with a higher risk of unfavorable outcomes.

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How to Cite
Rotchanapanya, W., Owattanapanich, W., & Chueamuangphan, N. (2019). Predictive Factors for Survival Outcomes of High-Risk Febrile Neutropenic Patients: a 3-Year Study at a Single Center in Thailand. Siriraj Medical Journal, 71(5), 339–348. https://doi.org/10.33192/Smj.2019.52
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Original Article