Outcomes of the Recombinant Human Epidermal Growth Factor Addition to Chloramphenicol Ointment for Facial Burn Wound Healing

Authors

  • Pornprom Muangman Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Nattakarn Changchit Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Kusuma Chinaroonchai Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0002-7764-3368
  • Nantaporn Namviriyachote Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Natthida Owattanapanich Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Harikrishna K.R. Nair Wound Care Unit, Department of Internal Medicine, Kuala Lumpur Hospital, Malaysia

DOI:

https://doi.org/10.33192/Smj.2019.65

Keywords:

Burn; wound healing; epidermal growth factor

Abstract

Objective: Delayed healing of facial burns can result in scarring and psychological morbidity. Epidermal growth factor may promote wound granulation and angiogenesis to enhance wound healing.  We compared the effect of Chloramphenicol ointment alone with Recombinant Human Epidermal Growth Factor (rhEGF) plus chloramphenicol on facial burn wound healing.
Methods: A randomized controlled trial was conducted in patients admitted to the Burn Unit. Subjects aged 18 to 65 years with acute second-degree facial burn wounds that did not require surgical treatment were enrolled. Subjects were divided equally and randomized to receive either topical chloramphenicol ointment twice daily (control) or rhEGF ointment once daily and chloramphenicol ointment twice daily. Wounds were assessed at frequent intervals. Wound size, complete healing day, pain score, infection, side effects, Vancouver Scar Scale and the cost of treatment were recorded.     
Results: Twenty-six wounds were enrolled. The mean wound size was similar in both groups (rhEGF plus chloramphenicol treated group 38.5±18.2 cm2 vs control group 42.1±19.4 cm2). Burn wounds in the rhEGF group healed more rapidly, though the difference was not statistically significant (8.5 ± 3.4 days vs 9.3 ± 4.4 days, p=0.3). No difference was observed in the Vancouver scar scale. Mean post-treatment pain scores were the same in both groups. There were no infections or side effects in either group. The rhEGF-treated group was more expensive (1463.1 ± 142.6 vs 19.2 ± 1.9 baht).
Conclusion:  There are no difference in outcomes of acute facial burn wound healing treated with rhEGF and chloramphenical ointment compared to chloramphenicol treatment alone. The further study to evaluate the effect of rhEGF in patients who have some factors that delay wound healing should be done.

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Published

15-11-2019

How to Cite

Muangman, P., Changchit, N., Chinaroonchai, K., Namviriyachote, N., Owattanapanich, N., & Nair, H. K. (2019). Outcomes of the Recombinant Human Epidermal Growth Factor Addition to Chloramphenicol Ointment for Facial Burn Wound Healing. Siriraj Medical Journal, 71(6), 438–445. https://doi.org/10.33192/Smj.2019.65

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Original Article