Presence of Residual Venous Thrombus at Warfarin Withdrawal: a Predictor for Recurrence after a First Episode of Symptomatic Provoked Proximal Deep Venous Thrombosis in Thai Population?

Kanin Pruekprasert; Chanean Ruangsetakit; Chumpol Wongwanit; Khamin Chinsakchai; Kiattisak Hongku; Nattawut Puangpanngam; Jutapim Khayankit; Tze Tec Chong; Nuttawut Sermsathanasawadi

doi:10.33192/Smj.2019.72

Presence of Residual Venous Thrombus at Warfarin Withdrawal: a Predictor for Recurrence after a First Episode of Symptomatic Provoked Proximal Deep Venous Thrombosis in Thai Population?

Authors

Kanin Pruekprasert Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0002-0262-2052
Chanean Ruangsetakit Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0003-1139-5012
Chumpol Wongwanit Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0002-8395-9852
Khamin Chinsakchai Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0001-8302-3184
Kiattisak Hongku Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0001-7405-3621
Nattawut Puangpanngam Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0002-4874-5285
Jutapim Khayankit Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0002-7696-7010
Tze Tec Chong Department of Vascular Surgery, Singapore General Hospital
Nuttawut Sermsathanasawadi Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0002-0674-1438

DOI:

https://doi.org/10.33192/Smj.2019.72

Keywords:

Deep vein thrombosis; duplex ultrasound; VTE management

Abstract

Objective: To assess the risk for venous thromboembolism (VTE) recurrence by presence of residual venous thrombus (RVT) at warfarin withdrawal following symptomatic first provoked proximal DVT.
Methods: Medical records of 45 consecutive patients with symptomatic first provoked proximal DVTs who had undergone warfarin surveillance for ≥ 3 months were reviewed retrospectively. Altogether, 22 patients discontinued anticoagulation after ≥ 3 months regardless of duplex ultrasonography results of RVT diagnosed by compression ultrasonography. Another 23 patients discontinued anticoagulation after the RVT disappeared. Primary outcome was recurrent VTE.
Results: Four of the 45 patients experienced recurrent VTE (8.89%), including 2 (9.00%) of 22 patients who had discontinued anticoagulant regardless of duplex ultrasonography results and 2 (8.70%) of 23 patients who discontinued anticoagulation after RVT disappearance (p = 0.963). All of the recurrent VTE were recurrent DVT.
Conclusion: RVT at warfarin withdrawal was not a predictor for recurrence VTE following a first symptomatic provoked proximal DVT.

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Published

18-11-2019

How to Cite

Pruekprasert, K., Ruangsetakit, C., Wongwanit, C., Chinsakchai, K., Hongku, K., Puangpanngam, N., … Sermsathanasawadi, N. (2019). Presence of Residual Venous Thrombus at Warfarin Withdrawal: a Predictor for Recurrence after a First Episode of Symptomatic Provoked Proximal Deep Venous Thrombosis in Thai Population?. Siriraj Medical Journal, 71(6), 486–490. https://doi.org/10.33192/Smj.2019.72

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Issue

Vol. 71 No. 6 (2019): November-December

Section

Original Article

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