Association of Oxcarbazepine-induced Cutaneous Adverse Drug Reactions with HLA-B*15:02 Allele

Main Article Content

Pramote Euasobhon
http://orcid.org/0000-0001-5268-5476
Sukunya Jirachaipitak
http://orcid.org/0000-0001-5188-3286
Suwanna Chanpradub
http://orcid.org/0000-0002-4742-6725
Pranee Rushatamukayanunt
http://orcid.org/0000-0003-3596-3598
Chanin Limwongse
http://orcid.org/0000-0002-7374-6765
Peter Courtney
http://orcid.org/0000-0002-5607-2711

Abstract

Objective: Oxcarbazepine (OXC) has similar structure and efficacy to carbamazepine (CBZ), but with fewer side effects. However, there have been only a few reports of serious cutaneous adverse reactions to OXC. HLA-B*15:02’s association with cutaneous adverse drug reactions (cADRs) induced by OXC is still inconsistent. This study investigated the incidence of cADRs that were induced by OXC and their association with the HLA-B*15:02 allele in Thais.
Methods:
A retrospective cohort study of 494 patients receiving oxcarbazepine between January 2012 and January 2018 was undertaken. HLA-B*15:02 testing had been carried out on 79 of the 494 patients.
Results:
No incidents of serious cutaneous adverse reactions, Stevens-Johnson syndrome (SJS), or toxic epidermal necrolysis (TEN) were found. A 2.4% (12/494) of OXC-related cADRs was determined. Four out of six patients with maculopapular eruptions (MPE) were HLA-B*15:02 positive. Patients who had the allele potentially developed OXC-induced MPE, with an odds ratio of 6.58 (95% CI 1.11-39.15, p=0.040). Only a history of other antiepileptic drug (AED) allergies demonstrated a significant risk factor of OXC-induced MPE.
Conclusion:
Our research demonstrated that the association between the HLA-B*15:02 allele and MPE induced by OXC was significant. Patients with a history of other AED allergies were also at risk of developing OXC-induced MPE.

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How to Cite
Euasobhon, P., Jirachaipitak, S., Chanpradub, S., Rushatamukayanunt, P., Limwongse, C., & Courtney, P. (2020). Association of Oxcarbazepine-induced Cutaneous Adverse Drug Reactions with HLA-B*15:02 Allele. Siriraj Medical Journal, 72(2), 174–180. https://doi.org/10.33192/Smj.2020.23
Section
Original Article

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