Derris Scandens Benth Extract Radiosensitizes HT-29 Colon Cancer Cells

Authors

  • Arunee Hematulin Department of Radiation Technology, Faculty of Allied Health Science,
  • Kornkanok Ingkaninan Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences
  • Nanteetip Limpeanchob Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000
  • Daniel Sagan Department of Radiation Technology, Faculty of Allied Health Science

Keywords:

Radiosensitizer; Derris scandens Benth;radiotherapy; medicinal plant; cancer

Abstract

Objective: To evaluate the radiosensitizing potential of Derris scandens extract in a human colon cancer cell model.
Methods: The radiosensitizing effect of D., scandens extract on human colon cancer cells (HT-29) and non-cancerous human retinal epithelial cells (RPE) was determined by cell survival and micronuclei analysis after irradiation. Cell cycle distribution was analyzed by a flow cytometer.
Results: D. scandens extract powerfully increases the radiosensitivity of HT-29 cells, but is less toxic and does not affect the radiosensitivity of RPE cells. Furthermore, the extract was found to reduce radiation-induced G2/M phase arrest in HT-29 cells, but not in RPE cells.
Conclusion: D., scandens extract may have potential as a radiosensitizer for cancer treatment.

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Published

03-04-2020

How to Cite

Hematulin, A. ., Ingkaninan, K. ., Limpeanchob, N. ., & Sagan, D. . (2020). Derris Scandens Benth Extract Radiosensitizes HT-29 Colon Cancer Cells. Siriraj Medical Journal, 63(3), 85–88. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/240917

Issue

Vol. 63 No. 3 (2011): May -June

Section

Original Article

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