A Randomised Controlled Trial of the Efficacy and Safety of 0.25% Desoximetasone Cream (Topoxy) Compared with 0.25% Desoximetasone Cream (Topicorte) for the Treatment of Scalp Psoriasis

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Leena Chularojanamontri
Narumol Silpa-archa
Pichanee Chaweekulrat
Chayanee Likitwattananurak
Puncharas Weerasubpong
Natchaya Junsuwan
Norramon Charoenpipatsin
Chanisada Wongpraparut


Objective: To compare the efficacy and safety of a generic desoximetasone cream (Topoxy) with the reference form, Topicorte, for the treatment of scalp psoriasis.
A randomised, double-blind, controlled study was conducted. Altogether, 105 patients with psoriasis lesions covering more than 10% of the scalp were randomised into three groups. The first, second and third groups received a placebo, Topoxy and Topicorte, respectively. The scalp psoriasis severities were assessed at weeks 0, 2, 4 and 8, using the Investigator Global Assessment (IGA) scale and Total Sign Score (TSS). The safety profiles of the products were assessed by the patients and physicians.
Topoxy and Topicorte were significantly more effective than the placebo in achieving at least a two-grade improvement in the IGA score from baseline at weeks 2, 4 and 8, and there were no significant differences between Topoxy and Topicorte. The TSS of both creams were significantly lower than that of the placebo at weeks 2, 4 and 8. All patients tolerated well to the therapy.
Topoxy and Topicorte had comparable efficacies for scalp psoriasis., The medications were superior to the placebo in all parameters, and  had a good safety profile.


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Chularojanamontri, L. ., Silpa-archa, N. ., Chaweekulrat, P., Likitwattananurak, C. ., Weerasubpong, P. ., Junsuwan, N. ., Charoenpipatsin, N. ., & Wongpraparut , C. . (2020). A Randomised Controlled Trial of the Efficacy and Safety of 0.25% Desoximetasone Cream (Topoxy) Compared with 0.25% Desoximetasone Cream (Topicorte) for the Treatment of Scalp Psoriasis. Siriraj Medical Journal, 72(5), 371–379. https://doi.org/10.33192/Smj.2020.50
Original Article


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