Insulin-like Growth Factor 1 Signalling and Its Role in Cell Survival and Radiation Sensitivity

Authors

  • Arunee Hematulin Department of Radiation Technology, Faculty of Allied Health Science, Naresuan University
  • Dr.rer. nat. Department of Radiation Technology, Faculty of Allied Health Science, Naresuan University

Keywords:

Insulin-like growth factor 1, survival, apoptosis, radiosensitivity

Abstract

Insulin like growth factor 1 signalling is a potent biological regulator for the growth and development in mammals. It controls tissue homeostasis throughout life via regulation of cell proliferation and apoptosis. Increased insulin like growth factor 1 signalling stimulates proliferation, promotes metastasis, and causes radio-resistance of cancer cells whereas decreased IGF-1 signalling is associated with increased incidence of cancer and enhanced cellular radio-sensitivity. The important role of insulin like growth factor 1 signalling as a pro-survival factor and its potential as a modifier of cellular radiosensitivity motivated research in the area of radiation oncology. Therefore this paper will review recent literatures on the insulin like growth factor 1 system and its role in cell survival and cellular response to radiation. The connection of IGF-1 signalling to classical pro-survival and anti-apoptotic signaling cascades will be reviewed.

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Published

31-07-2020

How to Cite

Hematulin, A. ., & nat. , . D. (2020). Insulin-like Growth Factor 1 Signalling and Its Role in Cell Survival and Radiation Sensitivity. Siriraj Medical Journal, 62(6), 263–267. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/244005

Issue

Vol. 62 No. 6 (2010): Nov-Dec

Section

Review Article

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