Insulin-like Growth Factor 1 Signalling and Its Role in Cell Survival and Radiation Sensitivity
Keywords:
Insulin-like growth factor 1, survival, apoptosis, radiosensitivityAbstract
Insulin like growth factor 1 signalling is a potent biological regulator for the growth and development in mammals. It controls tissue homeostasis throughout life via regulation of cell proliferation and apoptosis. Increased insulin like growth factor 1 signalling stimulates proliferation, promotes metastasis, and causes radio-resistance of cancer cells whereas decreased IGF-1 signalling is associated with increased incidence of cancer and enhanced cellular radio-sensitivity. The important role of insulin like growth factor 1 signalling as a pro-survival factor and its potential as a modifier of cellular radiosensitivity motivated research in the area of radiation oncology. Therefore this paper will review recent literatures on the insulin like growth factor 1 system and its role in cell survival and cellular response to radiation. The connection of IGF-1 signalling to classical pro-survival and anti-apoptotic signaling cascades will be reviewed.
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