Efficacy of Gymnostemma pentaphyllum in Patients with Hyperlipidemia

Authors

  • Somsak Sinsatienporn Pathumthani Hospital
  • Preyanuj Yamwong Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Anchalee Amornrat Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
  • Ubon Boonrod Pathumthani Hospital
  • Suchada Chaikajonpath Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
  • Jaree Bansiddhi Ministry of Public Health, Nonthaburi
  • Yenchit Techadamrongsin Ministry of Public Health, Nonthaburi
  • Malee Bunjob Ministry of Public Health, Nonthaburi
  • Visanu Thamlikitkul Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700

Keywords:

Gymnostemma pentaphyllum, Hyperlipidemia

Abstract

randomized double blind placebo controlled trial was conducted to determine the efficacy of Gymnostemma pentaphyllum in patients with hyperlipidemia. Twenty-three patients were allocated to receive Gymnostemma pentaphyllum powder in capsule at the dosage of 5 grams thrice a day for 3 months. Twenty-one patients received placebo in identical capsules thrice a day for 3 months. Lipid profiles (cholesterol, triglyceride, high density lipoprotein and low density lipoprotein) were determined prior to take medication and every month thereafter. Lipid profiles of all patients at entry were not significantly different from those after therapy. Lipid profiles of the patients in both groups at month 1, 2 and 3 were not significantly different. Oxidative stress & anti-oxidant activity and anti-platelet activity in the serum samples taken from patients in both groups were not significantly different. Adverse events and abnormal laboratory tests were not observed in patients receiving Gymnostemma pentaphyllum. Most of the patients were satisfied with the treatment they received. It is concluded that Gymnostemma pentaphyllum powder in capsules prepared by Department of Medical Sciences, Ministry of Public Health at the dosage of 5 grams thrice a day for 3 months is safe but not efficacious in reducing lipids in patients with hyperlipidemia.

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Published

11-08-2020

How to Cite

Sinsatienporn, S. ., Yamwong, P. ., Amornrat, A. ., Boonrod, U. ., Chaikajonpath, S. ., Bansiddhi, J. ., Techadamrongsin, Y. ., Bunjob, M. ., & Thamlikitkul, V. . (2020). Efficacy of Gymnostemma pentaphyllum in Patients with Hyperlipidemia. Siriraj Medical Journal, 53(2), 63–69. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/244055

Issue

Vol. 53 No. 2 (2001): February

Section

Original Article

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