Expression of p53, c-erbB-2 and Cathepsin D in Relation to Hormone Receptors in Primary Breast Cancer

Authors

  • Supornpim Chearskul Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
  • Kris Bhothisuwan Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Smarn Onreabroi Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
  • Malika Churintrapun Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
  • Namoiy Semprasert Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok

Keywords:

c-erbB-2, Cathepsin D, Hormone Receptors, Breast Cancer

Abstract

The immunohistochemical expression of p53, c-erbB-2, and cathepsin D oncogene proteins was examined in 494 primary breast carcinomas. This study aimed to investigate an association of expression of these three proteins with other variables known to be related to poor prognosis as well as with 5-year disease free survival (DFS). P53, c-erbB-2, and cathepsin D alone or in combination was negatively correlated with the presence of estrogen and progesterone receptors in breast cancer tissues. Alteration of these oncogenes rendering an expression of the proteins may affect the synthesis of steroid receptor proteins during the course of breast cancers. However, their significance as predictors of 5- year DFS was not achieved in this group of patients. Lymph node invasion was the only independent indicator for recurrent or metastatic breast carcinoma.

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Published

11-08-2020

How to Cite

Chearskul, S. ., Bhothisuwan, K. ., Onreabroi, S. ., Churintrapun, M. ., & Semprasert, N. . (2020). Expression of p53, c-erbB-2 and Cathepsin D in Relation to Hormone Receptors in Primary Breast Cancer. Siriraj Medical Journal, 53(4), 206–217. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/244107

Issue

Vol. 53 No. 4 (2001): April

Section

Original Article

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