The Effect of Antinuclear Antibody Patterns on Antineutrophil Cytoplasmic Antibody Test

Authors

  • Ronnachai Viriyataveekul Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Jintana Jaiyen Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Saikhwan Srijamroon Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Sumalee Potprasat Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700

Keywords:

Effect, Antinuclear Antibody, Antineutrophil Cytoplasmic Antibody Test

Abstract

Antineutrophil cytoplasmic antibody (ANCA) is used to diagnose and monitor activity in the primary systemic small vessel vasculitides. Serum samples with antinuclear antibody (ANA) interfere with the reading of neutrophil indirect immunofluorescence. The question arises, will ANA pattern affect the results of ANCA test differently? To answer this question, documents were retrospectively reviewed for the criteria of ANCA test with positive ANA from January 1 to December 31, 2000. Of 137 serum specimens with ANCA and ANA tests, 58 were positive for ANA test. The result showed that the number of positive P-ANCA with homogeneous pattern of ANA (88.9%) was statistically higher than that with speckled pattern (38.78%). In conclusion, there is a different effect of various ANA patterns on ANCA results. A further prospective study is required to confirm this result.

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Published

24-08-2020

How to Cite

Viriyataveekul, R. ., Jaiyen, J. ., Srijamroon, S. ., & Potprasat, S. . (2020). The Effect of Antinuclear Antibody Patterns on Antineutrophil Cytoplasmic Antibody Test. Siriraj Medical Journal, 53(7), 397–400. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/244661

Issue

Vol. 53 No. 7 (2001): July

Section

Original Article

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