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Our an objective was to study the efficacy of Capsaicin extracted from Capsaicin frutescen in treating the patients with hypersensitive bladder and primary detrusor instability. Eleven patients, 3 males and 8 females, with average age of 60.3 ± 14.3 years were treated by intravesical instillation 1 mM/L Capsaicin in 30% ethanol in an amount half of the bladder capacity for 30 minutes after instillation 2% xylocaine without adrenaline for 15 minutes three out of the 11 patients who could not tolerate the pain by this method were anesthesized with regional or general anesthesia.
Results: The results were as follow :-
1. Clinical symptoms were improved significantly, i e. the frequency was reduced from day : night = 19.45 Â± 17.99 : 7.09 ± 6.30 to 12.00 ± 8.91 : 4.09 ± 3.8 at p < 0.05 and leakage almost disappeared.
2. Maximal bladder capacity increased from 197.45 ± 156.06 ml to 323.45 ± 129.46 ml which was statistically significant (p=0.009).
3. Detrusor pressure at maximal bladder capacity increased from 32.63 ± 22.76 cmH2O to 36.63 ± 19.21 cmH2O but was not statistically significant (P=0.823).
4. Voiding pressure nonsignificantly increased from 47.1 ± 6.4 cmH2O to 48.1± 6.6 cmH2O (p=0.959).
The adverse effects found were burning pain at suprapubic area, sweating and hematuria.
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