The Efficacy of Thai Capsaicin in the Treatment of Primary Detrusor Instability and Hypersensitive Bladder

Authors

  • Bunjerd Nonthasood Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Suchai Soontrapa Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Teerapon Amornvesukit Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Pimolvan Tappayuthpijarn Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Thitiporn Suebnukanwattana Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok

Keywords:

Thai Capsaicin, Primary Detrusor Instability, Hypersensitive Bladder

Abstract

Our an objective was to study the efficacy of Capsaicin extracted from Capsaicin frutescen in treating the patients with hypersensitive bladder and primary detrusor instability. Eleven patients, 3 males and 8 females, with average age of 60.3 ± 14.3 years were treated by intravesical instillation 1 mM/L Capsaicin in 30% ethanol in an amount half of the bladder capacity for 30 minutes after instillation 2% xylocaine without adrenaline for 15 minutes three out of the 11 patients who could not tolerate the pain by this method were anesthesized with regional or general anesthesia.
Results: The results were as follow :-
1. Clinical symptoms were improved significantly, i e. the frequency was reduced from day : night = 19.45 ± 17.99 : 7.09 ± 6.30 to 12.00 ± 8.91 : 4.09 ± 3.8 at p < 0.05 and leakage almost disappeared.
 2. Maximal bladder capacity increased from 197.45 ± 156.06 ml to 323.45 ± 129.46 ml which was statistically significant (p=0.009).
 3. Detrusor pressure at maximal bladder capacity increased from 32.63 ± 22.76 cmH2O to 36.63 ± 19.21 cmH2O but was not statistically significant (P=0.823).
4. Voiding pressure nonsignificantly increased from 47.1 ± 6.4 cmH2O to 48.1± 6.6 cmH2O (p=0.959).
The adverse effects found were burning pain at suprapubic area, sweating and hematuria.

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Published

24-08-2020

How to Cite

Nonthasood, B. ., Soontrapa, S. ., Amornvesukit, T. ., Tappayuthpijarn, P. ., & Suebnukanwattana, T. . (2020). The Efficacy of Thai Capsaicin in the Treatment of Primary Detrusor Instability and Hypersensitive Bladder. Siriraj Medical Journal, 53(7), 406–413. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/244666

Issue

Vol. 53 No. 7 (2001): July

Section

Original Article

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