Significance of Thyroglobulin in Thyroid Diseases Detected by the Immunoperoxidase Method

Authors

  • Paisal Parichatikanond Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Tawee Laohapand Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Jutamanee Ngernmesri Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700
  • Kanittar Srisook Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700

Keywords:

Thyroglobulin, Thyroid, Immunoperoxidase Method

Abstract

Thyroglobulin (TG) is a protein that synthesized from the thyroid follicular epithelium and can reflect the thyroid gland in origin together with the cellular activity. The aim of this study is to detect TG qualitatively and semiquantitatively by immunoperoxidase method in various thyroid lesions. The result shows that all of the nodular goitre (43 cases), primary diffuse hyperplasia (18 cases), adenoma 60 cases, papillary carcinoma (43 cases) and follicular carcinoma (22 cases) show cytoplasmic staining of TG in varying pattern and intensity, while only 3 out of the 7 anaplastic carcinoma show irregular cytoplasmic staining.

These findings can be used in identifying the thyroid gland in origin in the metastatic lesion and the functional status of the lesion.

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Published

31-08-2020

How to Cite

Parichatikanond, P. ., Laohapand, T. ., Ngernmesri, J. ., & Srisook, K. . (2020). Significance of Thyroglobulin in Thyroid Diseases Detected by the Immunoperoxidase Method. Siriraj Medical Journal, 53(8), 509–516. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/244987

Issue

Vol. 53 No. 8 (2001): August

Section

Original Article

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