Effect of Oral Cilostazol on the Patency of Microvascular Anastomoses in Rats

Authors

  • Kolawach Laochaisri Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Apirag Chuangsuwanich Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Plernpit Panomreongsak Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Tuenjai Chuangsuwanich Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Podjana Laohaudomphan Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Surasak Muangsombut Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University

Keywords:

-

Abstract

In order to evaluate the effect of cilostazol on patency of microvascular anastomoses, a double blind control study was performed on microanastomoses of the femoral artery in rats. Thirty female Spraque- Dawley rats were divided into two groups according to a blind protocol. One group (group A) was given cilostazol orally (10 mg/ kg) 2 hours before the operation and for 7 days post-operatively. The other group (group B) received normal saline solution orally in the same amounts and at the same times as group A. The femoral artery anastomoses were performed under standard microvascular conditions. Seven days post-operatively, the patency of the arterial anatomoses was evaluated by Acland's test and histological study. The patency rate by Acland's test was 73% in group A, and 53% in group B. There was no significant difference between the patency rates of these two groups (p = 0.082). The area of the patency of the lumen by histological study was 61.67% in group A and 48% in group B. There was no significant difference between the groups in relation to patency of the microanastomoses (p = 0.381). There were no complications observed in this study.

Downloads

Published

01-02-2002

How to Cite

Laochaisri, K. ., Chuangsuwanich, A. ., Panomreongsak, P. ., Chuangsuwanich, T., Laohaudomphan, . P. ., & Muangsombut, S. . (2002). Effect of Oral Cilostazol on the Patency of Microvascular Anastomoses in Rats. Siriraj Medical Journal, 54(2), 81–86. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/245001

Issue

Vol. 54 No. 2 (2002): February

Section

Original Article

License

Users are free to share, copy, and redistribute all articles published in the Siriraj Medical Journal (SMJ) in any medium or format as long as you follow the following terms:

  • Attribution — You must give appropriate credit, provide a link to the material, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the publisher endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.