Pilot Study of the Efficacy and Safety of Nail Gel Containing Artemisia abrotanum Extract and Glycerin in the Treatment of Nail Plate Surface Abnormality

Supenya  Varothai; Sumanas Bunyaratavej; Charussri Leeyaphan; Sutasinee  Phaitoonwattanakij; Waranaree  Winayanuwattikun; Kanyalak Munprom

doi:10.33192/Smj.2021.27

Pilot Study of the Efficacy and Safety of Nail Gel Containing Artemisia abrotanum Extract and Glycerin in the Treatment of Nail Plate Surface Abnormality

Authors

Supenya Varothai Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. http://orcid.org/0000-0002-3740-0425
Sumanas Bunyaratavej Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0002-0852-7742
Charussri Leeyaphan Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0001-8430-376X
Sutasinee Phaitoonwattanakij Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0003-2591-1145
Waranaree Winayanuwattikun Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0001-7473-825X
Kanyalak Munprom Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 http://orcid.org/0000-0003-4349-3776

DOI:

https://doi.org/10.33192/Smj.2021.27

Keywords:

Artemisia abrotanum extract, Glycerin, nail gel, nail surface abnormality

Abstract

Background: Nail gels are utilized for the treatment of nails for nail plate surface abnormalities. However, the objective measurement of nail gel treatment is limited.

Objective: This study investigated the efficacy and safety of a nail gel containing glycerin and Artemisia abrotanum extract in treating nail plate surface abnormalities.

Material and Methods: All nails were evaluated with a Visiometer® system and by transonychial water loss (TOWL) at baseline, and at the 2nd and 8th weeks of treatment.

Results: In total, 19 patients with a mean age of 50.6 years old were enrolled and 50 nails were studied. Sixty percent of the patients showed significant clinical improvement, as determined by the total agreement between two treatment-blinded dermatologists. Regarding the Visiometer®, a significant reduction in the SER value (roughness) of the nail plates was found at the 2nd week, while at the 8th week, the surface and volume values had significantly decreased from baseline and also from the values at the 2nd week. There was a significant improvement in the Rku (smoothness) value at the 8th week compared to baseline. The mean TOWL at the 2nd and 8th weeks were statistically decreased from baseline. No side effects were detected.

Conclusions: This nail gel containing Artemisia abrotanum extract provided benefits in restoring hydration and improving the nail barrier in patients with nail surface abnormalities.

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Published

17-02-2021

How to Cite

Varothai, S. ., Bunyaratavej, S., Leeyaphan, C., Phaitoonwattanakij, S. ., Winayanuwattikun, W. ., & Munprom, K. (2021). Pilot Study of the Efficacy and Safety of Nail Gel Containing Artemisia abrotanum Extract and Glycerin in the Treatment of Nail Plate Surface Abnormality . Siriraj Medical Journal, 73(3), 204–208. https://doi.org/10.33192/Smj.2021.27

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Issue

Vol. 73 No. 3 (2021): March

Section

Original Article

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