Amikacin: Area Under Curve for Once Daily Dose and Its Correlation with Plasma Concentration at Six Hours Post Infusion

Authors

  • Teera Kolladaruengkri Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Kamol Udol Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Kantima Sangsiriwut Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Dujpratana Pisalsarakij Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Surapol Suwanagool Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University

Keywords:

Aminoglycosides, Amikacin, Area under curve

Abstract

Aminoglycosides are commonly used for gram-negative septicemia. Formerly, peak and trough plasma levels were the monitoring parameters for conventional dose which was every eight hours. At present the recommended dose is once daily and the recommended monitoring parameters are the area under concentration time curve and the six-hour (range 146-180) for the area under curve and 6.79 milligrams per liter (range 5.6-7.9) for the six-hour plasma concentration post-infusion. The correlation of the area under curve and the six-hour plasma concentration post-infusion was reported in a linear equation with significance.

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Published

01-03-2003

How to Cite

Kolladaruengkri, T. ., Udol, K. ., Sangsiriwut, K. ., Pisalsarakij, D. ., & Suwanagool, S. . (2003). Amikacin: Area Under Curve for Once Daily Dose and Its Correlation with Plasma Concentration at Six Hours Post Infusion. Siriraj Medical Journal, 55(3), 133–138. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/245387

Issue

Vol. 55 No. 3 (2003): March

Section

Original Article

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