Microalbumin Detection in Diabetes Mellitus Patients

Abstract

Diabetes nephropathy is one of the microangiopathic disorder in diabete mellitus patients. It can be predicted by mean of the microalbumin in urine. In this study, we determined microalbumin in 143 NIDDM patients, 24 men, 119 woman, aged 24-82 years old, in a random or early morning urine sample, by Immunoturbidimetric method. According to those urine samples were divided into three groups; normoalbuminuria (<20 mg/L, n = 74, 51.75%), microalbumin (20-200 mg/L, n = 55, 38.46%), and macroalbumin (>200 mg/L, n = 14, 9.79%). The microalbumin was significant correlation with years that cause diabetes mellitus (r = 0.204, P = 0.014), and mean arterial blood pressure (r = 0.244, P = 0.003). And the microalbumin was no significant correlation with blood glucose levels (r = -1.145, P = 0.084), patient' age (r = 0.039, P = 0.643), and proteinuria (r = 0.076, P = 0.365). The microalbumin determination was good correlation with microalbumin/ gm. of creatinine (r = 0.866, P = 0.0001). And the microalbumin/ gm. of creatinine was more sensitive than only measured microalbuminuria (mg/L) in urine to predict or prevent diabetic nephropathy.