Relationship of Human Papilloma Virus Infection and Abnormal Pap Smear in Human Immunodeficiency Virus Infected Women and Tendency to Develop Cervical Intraepithelial Neoplasia
Keywords:
Human papilloma virus, Abnormal Pap smear, Cervical intraepithelial neoplasiaAbstract
In HIV infected women, persistent human papilloma virus infection in their cervical tissue was found to have a direct relationship with the development of cervical intraepithelial neoplasia in their Pap smear examinations. In this study, we recruited 150 HIV infected women, whose major age-range was found to be between 20-35 years old (63.3%). HPV-DNA testing was positive in 55 cases, while Pap smear examinations were found to be abnormal in 25 cases (43.3%). Abnormal Pap smears were found atypical squamous cell of undeterminated significant (ASCUS) in 7 cases, low-grade squamous intraepithelial lesion (LSIL) 14 cases, and high-grade intraepithelial lesion 6 cases. A cervical biopsy was done in only 16 cases. Among them, 6 were found to have either moderate or higher-grade dysplasia. This study indicated that HIV infected women who had positive HPV-DNA testing were more likely to have abnormal Pap smears and had a tendency to develop moderate or higher grade of cervical dysplasia.
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