Leptin Level in Thai Children and Adolescents: Relation to BMI and Sexes

Authors

  • Katharee Chaichanwatanakul Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Praewvarin Weerakulwattana Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Sunattra Nunloi Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Chulaluk Komoltri Clinical Epidemiology Unit, Division of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University,
  • Pairunyar Nakavachara Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Jeerunda Santiprabhob Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Supawadee Likitmaskul Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University

Keywords:

BMI, Leptin, Non-obese, Obese

Abstract

Objective: The prevalence of obesity is rapidly increasing worldwide, including Thai children. Serum leptin is demonstrated largely that it increased in the dynamic phase in childhood - onset obesity. To our knowledge, there was no data of leptin measurement in this age group of our population.
Methods: Therefore, we measured serum leptin by an immunoradiometric assay in sample from 208 obese and non-obese healthy children aged 2-18 years old. Its relationship to body mass index (BMI), ages and sexes were analyzed.
Results: The mean serum leptin concentration in obese children was 35.06 ± 17.31 ng/ml compared with 14.70 ± 8.93 ng/ml in the non - obese children (p < 0.001). The obese female had significant higher level than in obese male group (43.26 ± 16.82 vs. 30.34 ± 15.85 ng/ml; p < 0.001), but they were not different in the non - obese group. The results showed that serum leptin correlated with BMI (r = 0.71; p < 0.001) and with % weight for height (%wt for ht) (r = 0.60, p < 0.001), respectively. Leptin levels in both sexes compared to age were also demonstrated. We did not find leptin deficiency or leptin resistance in all obese cases.
Conclusion: In summary, leptin level in Thai children were increased according to BMI, % wt for ht and sexes as demonstrated in other ethnic groups. However, there is neither leptin deficiency nor leptin resistance demonstrated in this study.

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Published

01-09-2006

How to Cite

Chaichanwatanakul, K. ., Weerakulwattana, P. ., Nunloi, . S. ., Komoltri, C. ., Nakavachara, P. ., Santiprabhob, J. ., & Likitmaskul, S. . (2006). Leptin Level in Thai Children and Adolescents: Relation to BMI and Sexes. Siriraj Medical Journal, 58(9), 1006–1009. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/245927

Issue

Vol. 58 No. 9 (2006): September

Section

Original Article

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