Theophylline Overdose in Premature Neonate: A Case Report and Review of Pharmacokinetics

Authors

  • Chulathida Chomchai Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Wilaslak Thanongsakakul Ao-Udom Hospital, Sriracha, Chonburi
  • Wisit Thanyong Ao-Udom Hospital, Sriracha, Chonburi

Keywords:

Adverse drug reaction, drug overdose, neonates, medication errors, theophylline

Abstract

Theophylline is well-accepted in neonatal medicine for its efficacy in treating apneas of prematurity. However, due to its narrow therapeutic index, decreased drug elimination capacity and limitations of enhanced elimination methods in premature newborns, inadvertent overdoses in this age group can be difficult to manage. We report a case of therapeutic misadventure of a 30-week-old infant who received and overdose of aminophylline for apnea of prematurity. The patient was symptomatic with tachycardia, agitation, vomiting, hyperglycemia and diuresis. He received an exchange transfusion 9 hours after the overdose and had progressive resolution of symptoms. The pharmacokinetics of theophylline in cases of overdose in the neonates is reviewed.

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Published

01-09-2006

How to Cite

Chomchai, C. ., Thanongsakakul, W. ., & Thanyong, W. . (2006). Theophylline Overdose in Premature Neonate: A Case Report and Review of Pharmacokinetics. Siriraj Medical Journal, 58(9), 1013–1015. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/245929

Issue

Vol. 58 No. 9 (2006): September

Section

Case Report

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