Prevention of Indomethacin - Induced Gastric Ulcers in Rats by Extract from Leaves of Centella asiatica

Authors

  • Kittisak Sripanidkulchai Department of Anatomy, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Nawaporn Techataweewan Department of Anatomy, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Bungorn Sripanidkulchai Department of Pharmaceutical Chemistry and Center for Research and Development of Herbal Health Products, Faculty of Pharmaceutical Sciences, Khon Kaen University

Keywords:

Centella asiatica, gastric ulcer, indomethacin

Abstract

Objective: The aim of this study is to investigate the protective effect of Centella asiatica extract on gastric ulcers caused by indomethacin in rats.

Methods: Male rats were orally given extract of C.asiatica prior to the administration of indomethacin. The stomach was dissected and the number of bleeding spots and histological features were determined.

Results: Giving extract of C.asiatica at doses of 10 and 20 mg/kg for 30 minutes prior to oral administration of indomethacin decreased the number of bleeding spots are about 11 times lower than those given indomethacin alone. Histological findings of indomethacin-treated group showed the depth of injury of gastric mucosa which is about half the thickness of the mucosal layer. Treatment with C.asiatica decreased the depth of tissue erosion, down to one-third of the thickness of the mucosa.

Conclusion: The results showed protective effect of C.asiatica on gastric ulceration caused by the anti-inflammatory drug, indomethacin.

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Published

01-03-2007

How to Cite

Sripanidkulchai, K. ., Techataweewan, N. ., & Sripanidkulchai, . B. . (2007). Prevention of Indomethacin - Induced Gastric Ulcers in Rats by Extract from Leaves of Centella asiatica. Siriraj Medical Journal, 59(3), 122–124. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/246074

Issue

Vol. 59 No. 3 (2007): May-June

Section

Original Article

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