Estrogen Reduced Blood Glucose in High Fat-Fed Mice: An Animal Model of Type 2 Diabetes

Authors

  • Suwattanee Kooptiwut Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Namoiy Semprasert Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Smarn Onreabroi Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University

Keywords:

Blood glucose, C57BL/6J mice, estrogen, high fat diet, type 2 diabetes

Abstract

Objective: This study aims to produce a mouse model of type 2 diabetes by using high fat diet. The C57BL/6J mouse strain can develop type 2 diabetes by putting on high fat diet.

Methods: A group of C57BL/6J male mice were fed with a high fat diet (53% energy by fat) while another group was fed with normal diet (4.5% energy by fat).

Results: At the 16th week of feeding study, the high fat-fed mice developed type 2 diabetes and had higher fat-pad weight than the normal diet-fed mice. However, plasma triglyceride (TG) levels of the two groups were not different. High fat-induced diabetic mice were administered 0.2 μg/g body weight of 17-β estradiol for 2 weeks. Their fasting blood levels were reduced to become lesser than the levels in high-fat fed mice without estrogen. A trend of decrease in plasma TG level of 17-β estradiol treated mice was observed.

Conclusion: This study demonstrated that high fat diet could induce type 2 diabetes in a mouse model and that estrogen could reduce the fasting blood glucose in these mice.

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Published

01-07-2007

How to Cite

Kooptiwut, S. ., Semprasert, N. ., & Onreabroi, S. . (2007). Estrogen Reduced Blood Glucose in High Fat-Fed Mice: An Animal Model of Type 2 Diabetes. Siriraj Medical Journal, 59(4), 164–167. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/246091

Issue

Vol. 59 No. 4 (2007): Jul-Aug

Section

Original Article

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