Low Serum Vitamin B12 in Alzheimerûs Patients as Detected by a Solid Phase Radioimmunoassay

Authors

  • Areechun Sotthibundhu Neuro-Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University
  • Doungjai Buntup Neuro-Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University
  • Channarong Sanghirun Department of Tropical Radioisotopes, Faculty of Tropical Medicine, Ramathibodi Hospital
  • Korbkit Cherdchu Department of Tropical Radioisotopes, Faculty of Tropical Medicine, Ramathibodi Hospital
  • Cheeraratana Cheeramakara Department of Tropical Radioisotopes, Faculty of Tropical Medicine, Ramathibodi Hospital
  • Sirintorn Chansirikarnjan Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Ekapot Nimkulrat Department of Medicine, Phraram 9 Hospital
  • Chesda Udommongkol Division of Neurology, Department of Medicine, Phramongkutklao Hospital
  • Wanna Wongmek Division of Neurology, Department of Medicine, Phramongkutklao Hospital
  • Wipawan Thangnipon Neuro-Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University

Keywords:

Alzheimerûs disease, folate and vitamin B12

Abstract

Objective: To determine the relationship between serum levels of vitamin B12 and folate in AD and other types of dementia in Thai patients.
Methods: One hundred and eleven Thai subjects were classified into 3 groups: 32 AD patients, 43 non-AD dementia patients and 36 age-matched controls. Serum concentrations of vitamin B12 and folate were measured using a solid phase radioimmunoassay.
Results: Serum vitamin B12 levels were found to be significantly lower in AD and non-AD dementia patients than in age-matched controls. There is a significant relationship between Mini-Mental State Examination score and vitamin B12 level in AD and non-AD dementia groups. However, there is no significant difference in serum folate in AD and non-AD dementia groups when compared to age-matched controls.
Conclusion: These findings suggest the need for vitamin B12 supplementation in AD and non-AD dementia patients.

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Published

01-01-2008

How to Cite

Sotthibundhu, A. ., Buntup, D. ., Sanghirun, C. ., Cherdchu, K., Cheeramakara, C. ., Chansirikarnjan, S. ., Nimkulrat, E. ., Udommongkol, C. ., Wongmek, W. ., & Thangnipon, W. . (2008). Low Serum Vitamin B12 in Alzheimerûs Patients as Detected by a Solid Phase Radioimmunoassay. Siriraj Medical Journal, 60(1), 66–68. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/246322

Issue

Vol. 60 No. 1 (2008): Jan-Feb

Section

Original Article

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