Low Serum Vitamin B12 in Alzheimerûs Patients as Detected by a Solid Phase Radioimmunoassay

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Published: Jan 1, 2008
Keywords:
Alzheimerûs disease folate and vitamin B12

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Areechun Sotthibundhu
Neuro-Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University
Doungjai Buntup
Neuro-Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University
Channarong Sanghirun
Department of Tropical Radioisotopes, Faculty of Tropical Medicine, Ramathibodi Hospital
Korbkit Cherdchu
Department of Tropical Radioisotopes, Faculty of Tropical Medicine, Ramathibodi Hospital
Cheeraratana Cheeramakara
Department of Tropical Radioisotopes, Faculty of Tropical Medicine, Ramathibodi Hospital
Sirintorn Chansirikarnjan
Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
Ekapot Nimkulrat
Department of Medicine, Phraram 9 Hospital
Chesda Udommongkol
Division of Neurology, Department of Medicine, Phramongkutklao Hospital
Wanna Wongmek
Division of Neurology, Department of Medicine, Phramongkutklao Hospital
Wipawan Thangnipon
Neuro-Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University

Abstract

Objective: To determine the relationship between serum levels of vitamin B12 and folate in AD and other types of dementia in Thai patients.
Methods: One hundred and eleven Thai subjects were classified into 3 groups: 32 AD patients, 43 non-AD dementia patients and 36 age-matched controls. Serum concentrations of vitamin B12 and folate were measured using a solid phase radioimmunoassay.
Results: Serum vitamin B12 levels were found to be significantly lower in AD and non-AD dementia patients than in age-matched controls. There is a significant relationship between Mini-Mental State Examination score and vitamin B12 level in AD and non-AD dementia groups. However, there is no significant difference in serum folate in AD and non-AD dementia groups when compared to age-matched controls.
Conclusion: These findings suggest the need for vitamin B12 supplementation in AD and non-AD dementia patients.

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How to Cite
Sotthibundhu, A. ., Buntup, D. ., Sanghirun, C. ., Cherdchu, K., Cheeramakara, C. ., Chansirikarnjan, S. ., Nimkulrat, E. ., Udommongkol, C. ., Wongmek, W. ., & Thangnipon, W. . (2008). Low Serum Vitamin B12 in Alzheimerûs Patients as Detected by a Solid Phase Radioimmunoassay. Siriraj Medical Journal, 60(1), 66–68. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/246322
Issue
Vol. 60 No. 1 (2008): Jan-Feb
Section
Original Article

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