Low Serum Vitamin B12 in Alzheimerûs Patients as Detected by a Solid Phase Radioimmunoassay

Main Article Content

Areechun Sotthibundhu
Doungjai Buntup
Channarong Sanghirun
Korbkit Cherdchu
Cheeraratana Cheeramakara
Sirintorn Chansirikarnjan
Ekapot Nimkulrat
Chesda Udommongkol
Wanna Wongmek
Wipawan Thangnipon

Abstract

Objective: To determine the relationship between serum levels of vitamin B12 and folate in AD and other types of dementia in Thai patients.
Methods: One hundred and eleven Thai subjects were classified into 3 groups: 32 AD patients, 43 non-AD dementia patients and 36 age-matched controls. Serum concentrations of vitamin B12 and folate were measured using a solid phase radioimmunoassay.
Results: Serum vitamin B12 levels were found to be significantly lower in AD and non-AD dementia patients than in age-matched controls. There is a significant relationship between Mini-Mental State Examination score and vitamin B12 level in AD and non-AD dementia groups. However, there is no significant difference in serum folate in AD and non-AD dementia groups when compared to age-matched controls.
Conclusion: These findings suggest the need for vitamin B12 supplementation in AD and non-AD dementia patients.


 

Downloads

Download data is not yet available.

Article Details

How to Cite
Sotthibundhu, A. ., Buntup, D. ., Sanghirun, C. ., Cherdchu, K., Cheeramakara, C. ., Chansirikarnjan, S. ., Nimkulrat, E. ., Udommongkol, C. ., Wongmek, W. ., & Thangnipon, W. . (2008). Low Serum Vitamin B12 in Alzheimerûs Patients as Detected by a Solid Phase Radioimmunoassay. Siriraj Medical Journal, 60(2), 66–68. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/246358
Section
Original Article