Preliminary Data of Preimplantation Genetic Diagnosis for Aneuploidy Screening

Authors

  • Japarath Prechapanich Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Roungsin Choavaratana Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Pitak Laokirkkiat Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Somsin Petyim Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Orawan Mekmahan Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University

Keywords:

Preimplantation genetic diagnosis (PGD), preimplantation genetic diagnosis for aneuploidy screening (PGD-AS), fluorescent in situ hybridization (FISH)

Abstract

Objective: Preimplantation genetic diagnosis (PGD) is technique for detecting genetic diseases. Preimplantation genetic diagnosis for aneuploidy screening (PGD-AS) using fluorescent in situ hybridization (FISH) has been used worldwide including at Siriraj Hospital. The objective of this study was to compare the pregnancy rate between a PGD-AS group with standard assisted reproductive techniques (ARTs) in Siriraj Hospital.
Methods: Couples who requested PGD-AS underwent a standard ARTs process followed with blastomere biopsy for FISH analysis. The pregnancy rate was compared among the PGD-AS group and the control group. The control group was divided into 2 subgroups – all patients required ARTs subgroup and age ≥ 35 yrs. subgroup.
Results: 6 stimulated cycles from 4 patients were performed in the PGD-AS group. The pregnancy rate per stimulated cycle in the PGD-AS group, control group and age ≥ 35 yrs group were 33.33%, 16.20% and 12.05% respectively. Moreover, the pregnancy rate per transferred cycles in the PGD-AS group, control group and age ≥ 35 yrs group were 40.00%, 21.02% and 13.17% respectively.
Conclusion: PGD is an advanced method for detecting genetic defects. PGA-AS might increase the pregnancy rate.Â

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Published

01-11-2008

How to Cite

Prechapanich, J. ., Choavaratana, R. ., Laokirkkiat, P. ., Petyim, S. ., & Mekmahan, O. . (2008). Preliminary Data of Preimplantation Genetic Diagnosis for Aneuploidy Screening. Siriraj Medical Journal, 60(6), 344–348. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/246508

Issue

Vol. 60 No. 6 (2008): Nov-Dec

Section

Original Article

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