Hepatocellular Carcinoma : Correlation of Histological Grading with Immunohistochemical Identification of Proliferative Hepatocytes with PC 10

Authors

  • Kanit Atisook Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Chavaboon Dechsukum Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Chalengpoj Sthapanachai Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Nusara Wongwisitsak Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University

Keywords:

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Abstract

Sections from 31 liver needle biopsies of hepatocellular carcinomas (HCCs) were examined for the histological grading of tumors with the expression of a labelling index, using monoclonal antibodies to proliferating cell nuclear antigen PC-10. The correlation between histological grading and the labelling index showed a statistically significant increase in the labelling index in grades III to IV of HCCs. A cut-off point of the labelling index at 49 per cent was proposed to indicate the prognosis of the patient. HCCs with a labelling index below 49 per cent has a better prognosis than HCCs with a labelling index above 49 per cent. A combination of histological grading and the labelling index indicated the prognosis of the patients with HCCs.

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Published

01-02-1999

How to Cite

Atisook, K. ., Dechsukum, C. ., Sthapanachai, C. ., & Wongwisitsak, N. . (1999). Hepatocellular Carcinoma : Correlation of Histological Grading with Immunohistochemical Identification of Proliferative Hepatocytes with PC 10. Siriraj Medical Journal, 51(2), 71–76. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/246869

Issue

Vol. 51 No. 2 (1999): February

Section

Original Article

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